(R)-1-(4-Methoxy-phenoxy)-3-trityloxy-propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (R)-1-(4-Methoxy-phenoxy)-3-trityloxy-propan-2-ol
• 英文别名: (2R)-1-(4-methoxyphenoxy)-3-trityloxypropan-2-ol
• 化学式: C₂₉H₂₈O₄
• 分子量: 440.539
• InChiKey: QNOZQOAYUTUOGV-AREMUKBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-1-(4-Methoxy-phenoxy)-3-trityloxy-propan-2-ol 在 吡啶 、 sodium azide 、 Amberlyst-R₁₅ (H+) 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 (R)-2-azido-3-O-p-methoxyphenyl-1,3-propanediol
  参考文献：
  名称：

  Synthesis and absolute configuration of a novel aminoglycoglycerolipid, species-specific major immunodeterminant of Mycoplasma fermentans

  摘要：

  In order to determine the absolute configuration of a novel aminoglycoglycerolipid isolated from Mycoplasma fermentans, the possible two diastereomers were stereoselectively synthesized by using (S)- and (R)-glycidols as the key building block. Their H-1-H-1-cosy spectra compared with those of the natural product allowed us to determine the absolute configuration of the glycolipid. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00191-4
• 作为产物：
  描述：

  4-甲氧基苯基氧化钠 、 三苯甲基-(R)-缩水甘油醚 以 N,N-二甲基甲酰胺 为溶剂， 以99%的产率得到(R)-1-(4-Methoxy-phenoxy)-3-trityloxy-propan-2-ol
  参考文献：
  名称：

  Synthesis and absolute configuration of a novel aminoglycoglycerolipid, species-specific major immunodeterminant of Mycoplasma fermentans

  摘要：

  In order to determine the absolute configuration of a novel aminoglycoglycerolipid isolated from Mycoplasma fermentans, the possible two diastereomers were stereoselectively synthesized by using (S)- and (R)-glycidols as the key building block. Their H-1-H-1-cosy spectra compared with those of the natural product allowed us to determine the absolute configuration of the glycolipid. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00191-4

文献信息

• Synthesis and absolute configuration of a novel aminoglycoglycerolipid, species-specific major immunodeterminant of Mycoplasma fermentans
  作者：Yoshihiro Nishida、Yusuke Takamori、Hiroshi Ohrui、Ineo Ishizuka、Kazuhiro Matsuda、Kazukiyo Kobayashi

  DOI：10.1016/s0040-4039(99)00191-4

  日期：1999.3

  In order to determine the absolute configuration of a novel aminoglycoglycerolipid isolated from Mycoplasma fermentans, the possible two diastereomers were stereoselectively synthesized by using (S)- and (R)-glycidols as the key building block. Their H-1-H-1-cosy spectra compared with those of the natural product allowed us to determine the absolute configuration of the glycolipid. (C) 1999 Elsevier Science Ltd. All rights reserved.