8-[3-[4-(2-quinolinyl)-1-piperazinyl]propyloxy]-8-azaspiro[4.5]decan-7,9-dione | 118856-32-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 8-[3-[4-(2-quinolinyl)-1-piperazinyl]propyloxy]-8-azaspiro[4.5]decan-7,9-dione
• 英文别名: 8-[3-(4-Quinolin-2-yl-piperazin-1-yl)-propoxy]-8-aza-spiro[4.5]decane-7,9-dione；8-[3-(4-quinolin-2-ylpiperazin-1-yl)propoxy]-8-azaspiro[4.5]decane-7,9-dione
• CAS: 118856-32-9
• 化学式: C₂₅H₃₂N₄O₃
• 分子量: 436.554
• InChiKey: BYFYQDNROZOLIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  66
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  8-<(3-bromopropyl)oxy>-8-azaspiro<4.5>decane-7,9-dione 生成 8-[3-[4-(2-quinolinyl)-1-piperazinyl]propyloxy]-8-azaspiro[4.5]decan-7,9-dione
  参考文献：
  名称：

  HRIB, NICHOLAS J.;JURCAK, JOHN G.

  摘要：

  DOI：

文献信息

• Arylpiperazinylalkoxy derivatives of cyclic imides
  申请人：Hoechst-Roussel Pharmaceuticals, Inc.

  公开号：US04780466A1

  公开（公告）日：1988-10-25

  There are disclosed compounds of the formula ##STR1## wherein the group A is ##STR2## where R.sub.1 and R.sub.2 are each independently hydrogen or loweralkyl, or R.sub.1 +R.sub.2 =(CH.sub.2).sub.m, m being 2 to 6, p is 1 or 2, and each X is independently hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, amino, loweralkylamino, diloweralkylamino, trifluoromethyl or loweralkylthio; W is O, H.sub.2 or [H, OH]; n is 2, 3 or 4; and R.sub.3 is ##STR3## where q is 1 or 2 and each Y is independently hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, amino, loweralkylamino, diloweralkylamino, trifluoromethyl or loweralkylthio, which are useful as antipsychotic, anxiolytic and analgesic agents.

  公开了化合物的公式，其中A基团为##STR2##其中R.sub.1和R.sub.2各自独立地为氢或较低烷基，或R.sub.1 + R.sub.2 =（CH.sub.2）.sub.m，其中m为2至6，p为1或2，每个X独立地为氢，较低烷基，较低烷氧基，卤素，羟基，硝基，氨基，较低烷基氨基，二较低烷基氨基，三氟甲基或较低烷基硫代基; W为O，H.sub.2或[H，OH]；n为2、3或4；R.sub.3为##STR3##其中q为1或2，每个Y独立地为氢，较低烷基，较低烷氧基，卤素，羟基，硝基，氨基，较低烷基氨基，二较低烷基氨基，三氟甲基或较低烷基硫代基，这些化合物可用作抗精神病、抗焦虑和镇痛剂。
• Arylpiperazinylalkoxy derivatives of cyclic imides to treat anxiety
  申请人：Hoechst-Roussel Pharmaceuticals, Inc.

  公开号：US04826846A1

  公开（公告）日：1989-05-02

  There are disclosed compounds of the formula ##STR1## wherein the group A is ##STR2## where R.sub.1 and R.sub.2 are each independently or loweralkyl, or R.sub.1 +R.sub.2 =(CH.sub.2).sub.m, m being 2 to 6, p is 1 or 2, and each X is independently hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, amino, loweralkylamino, diloweralkylamino, trifluoromethyl or loweralkylthio; W is O, H.sub.2 or [H, OH]; n is 2, 3 or 4; and R.sub.3 is ##STR3## where q is 1 or 2 and each Y is independently hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, amino, loweralkylamino, diloweralkylamino, triflouromethyl or loweralkylthio, which are useful as antipsychotic, anxiolytic and analgesic agents.

  公开了式子为##STR1##的化合物，其中A基团为##STR2##，其中R.sub.1和R.sub.2各自独立地为较低烷基，或R.sub.1 +R.sub.2 =(CH.sub.2).sub.m，m为2到6，p为1或2，每个X独立地为氢、较低烷基、较低烷氧基、卤素、羟基、硝基、氨基、较低烷基氨基、二较低烷基氨基、三氟甲基或较低烷基硫基; W为O，H.sub.2或[H，OH];n为2、3或4; R.sub.3为##STR3##，其中q为1或2，每个Y独立地为氢、较低烷基、较低烷氧基、卤素、羟基、硝基、氨基、较低烷基氨基、二较低烷基氨基、三氟甲基或较低烷基硫基，这些化合物可用作抗精神病、抗焦虑和镇痛剂。
• Arylpiperazinylalkoxy derivatives of cyclic imides, a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0333137A1

  公开（公告）日：1989-09-20

  There are disclosed compounds of the formula wherein the group A is where R₁ and R₂ are each independently hydrogen or loweralkyl, or R₁ + R₂ = (CH₂)m, m being 2 to 6, p is 1 or 2, and each X is independently hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, amino, loweralkylamino, diloweralkylamino, trifluoromethyl or loweralkylthio; W is O, H₂ or [H, OH]; n is 2, 3 or 4; and R₃ is where q is 1 or 2 and each Y is independently hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, amino, loweralkylamino, diloweralkylamino, trifluoromethyl or loweralkylthio, and a process for their preparation. The compounds of the present invention are useful as anti-­psychotic, anxiolytic or analgesic agents.

  公开了如下式的化合物 其中基团 A 为 其中 R₁ 和 R₂ 各自独立地为氢或低级烷基，或 R₁ + R₂ = (CH₂)m，m 为 2 至 6，p 为 1 或 2，且每个 X 独立地为氢、低级烷基、低级烷氧基、卤素、羟基、硝基、氨基、低级烷基氨基、稀释烷基氨基、三氟甲基或低级烷硫基；W 是 O、H₂ 或 [H，OH]； n 是 2、3 或 4；以及 R₃ 是 其中 q 是 1 或 2，每个 Y 独立地是氢、低级烷基、低级烷氧基、卤素、羟基、硝基、氨基、低级烷基氨基、稀释烷基氨基、三氟甲基或低级烷硫基，以及它们的制备方法。 本发明的化合物可用作抗精神病药、抗焦虑药或镇痛药。
• HRIB, NICHOLAS J.;JURCAK, JOHN G.
  作者：HRIB, NICHOLAS J.、JURCAK, JOHN G.

  DOI：——

  日期：——
• HRIB, NICHOLAS J.;JURCAK, JOHN G.;HUGER, FRANCIS P.;ERRICO, CHERI L.;DUNN+, J. MED. CHEM., 34,(1991) N, C. 1068-1072
  作者：HRIB, NICHOLAS J.、JURCAK, JOHN G.、HUGER, FRANCIS P.、ERRICO, CHERI L.、DUNN+

  DOI：——

  日期：——