4-(5-methoxy-1,2-benzisoxazolyl)piperidine hydrochloride | 84163-14-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并异恶唑
• 英文名称: 4-(5-methoxy-1,2-benzisoxazolyl)piperidine hydrochloride
• 英文别名: 5-methoxy-3-(4-piperidyl)-1,2-benzisoxazole hydrochloride；5-methoxy-3-piperidin-4-yl-1,2-benzoxazole;hydrochloride
• CAS: 84163-14-4
• 化学式: C₁₃H₁₆N₂O₂*ClH
• 分子量: 268.743
• InChiKey: IKKJRRZJRGMHIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.73
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  47.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,4,-二(4-氟苯)氯丁烷 、 4-(5-methoxy-1,2-benzisoxazolyl)piperidine hydrochloride 生成 3-{1-[4,4-bis(4-Fluorophenyl)-1-butyl]-4-piperidyl}-5-methoxy-1,2-benzisoxazole hydrobromide
  参考文献：
  名称：

  STRUPCZEWSKI, J. T.;ALLEN, R. C.

  摘要：

  DOI：
• 作为产物：
  描述：

  1-acetyl-4-(2-hydroxy-5-methoxybenzoyl)piperidine oxime 在 盐酸 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 23.5h， 生成 4-(5-methoxy-1,2-benzisoxazolyl)piperidine hydrochloride
  参考文献：
  名称：

  Synthesis and neuroleptic activity of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles

  摘要：

  The synthesis of a series of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles is described. The neuroleptic activity of the series was evaluated by utilizing the climbing mice assay and inhibition of [3H]spiroperidol binding. Structure-activity relationships were studied by variation of the substituent on the benzisoxazole ring with concomitant variation of four different 1-piperidinyl substituents. Maximum neuroleptic activity was realized when there was a 6-fluoro substituent on the benzisoxazole ring. The 1-piperidinyl substituent appeared less significant, although in most cases, the (1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl group imparted maximum potency. The most potent compound in both assays was 6-fluoro-3-[1-[3-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl) propyl]-4-piperidinyl]-1,2-benzisoxazole (11b).

  DOI：

  10.1021/jm00383a012

文献信息

• 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04352811A1

  公开（公告）日：1982-10-05

  Novel 3-(1-substituted-4-piperidyl)-1,2-benzisoxazoles, processes for the preparation thereof, and methods of treating psychoses employing compounds and compositions thereof are disclosed.

  揭示了新型3-(1-取代-4-哌啶基)-1,2-苯并异噁唑类化合物，其制备方法，以及利用这些化合物和组合物治疗精神病的方法。
• Aralkyl Substituted Piperidine or Piperazine Derivatives and Their Use for Treating Schizophrenia
  申请人：Li Jianqi

  公开号：US20110160199A1

  公开（公告）日：2011-06-30

  The present invention discloses an aralkyl substituted piperidine or piperazine derivative and the use of the derivative in preparation of medicaments for treating schizophrenia and correlative psychoneuroses. It is shown by pharmacological tests that the derivative of the present invention has better antischizophrenic effect and less toxicity. Said derivative is a free base or salt of the compound having the following general formula.

  本发明揭示了一种芳基烷基取代的哌啶或哌嗪衍生物，以及该衍生物在制备治疗精神分裂症和相关精神神经症的药物中的应用。药理学测试表明，本发明的衍生物具有更好的抗精神分裂症效果和较小的毒性。所述衍生物是以下一般式化合物的自由碱基或盐。
• Aralkyl substituted piperidine or piperazine derivatives and their use for treating schizophrenia
  申请人：Li Jianqi

  公开号：US08653069B2

  公开（公告）日：2014-02-18

  The present invention discloses an aralkyl substituted piperidine or piperazine derivative and the use of the derivative in preparation of medicaments for treating schizophrenia and correlative psychoneuroses. It is shown by pharmacological tests that the derivative of the present invention has better antischizophrenic effect and less toxicity. Said derivative is a free base or salt of the compound having the following general formula.

  本发明公开了一种芳基烷基取代的哌啶或哌嗪衍生物及其在制备治疗精神分裂症和相关精神神经症的药物中的应用。药理学测试表明，本发明的衍生物具有更好的抗精神分裂症作用和更少的毒性。所述衍生物是具有以下通式的化合物的自由碱基或盐。
• 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles, a process for the preparation thereof, a pharmaceutical composition comprising the same, and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0079564A1

  公开（公告）日：1983-05-25

  Novel 3-(1-substituted-4-piperidyl)-1,2-benzisoxazoles, of the formula 1 wherein X is halogen, loweralkyl, loweralkoxy or hydroxy and m is 0, 1 or 2, R is a group of the formula wherein n is 2 or 3; a group of the formula wherein n is 2 or 3; a group of the formula wherein n is 2 or 3; a group of the formula wherein R, and R2 are each independently hydrogen or loweralkyl, R3 is hydrogen, halogen or loweralkyl and n is 2 or 3: a group of the formula wherein R4 is hydrogen or loweralkyl, R5 is hydrogen, halogen or loweralkyl; and n is 2 or 3; and a group of the formula the optical antipodes thereof; or pharmaceutically acceptable acid addition salts thereof. processes for the preparation thereof, their use for treating psychoses and compositions thereof are disclosed.

  式 1 的新型 3-(1-取代-4-哌啶基)-1,2-苯并异噁唑 其中 X 为卤素、低级烷基、低级烷氧基或羟基，m 为 0、1 或 2，R 为式中的基团 式中 n 为 2 或 3 的基团 式中 n 为 2 或 3 的基团 式中 n 为 2 或 3 的基团 其中 R 和 R2 各自独立地为氢或低级烷基，R3 为氢、卤素或低级烷基，且 n 为 2 或 3 的式子的基团 其中 R4 是氢或低级烷基，R5 是氢、卤素或低级烷基，且 n 是 2 或 3；以及式中的基团 其光学反义词；或其药学上可接受的酸加成盐。 公开了其制备工艺、治疗精神病的用途及其组合物。
• ARALKYL SUBSTITUTED PIPERIDINE OR PIPERAZINE DERIVATIVES AND THEIR USE FOR TREATING SCHIZOPHRENIA
  申请人：Jiangsu Guohua Investment Co., Ltd

  公开号：EP2322520A1

  公开（公告）日：2011-05-18

  The present invention discloses an aralkyl substituted piperidine or piperazine derivative and the use of the derivative in preparation of medicaments for treating schizophrenia and correlative psychoneuroses. It is shown by pharmacological tests that the derivative of the present invention has better antischizophrenic effect and less toxicity. Said derivative is a free base or salt of the compound having the following general formula.

  本发明公开了一种芳基取代的哌啶或哌嗪衍生物，以及该衍生物在制备治疗精神分裂症和相关精神神经症的药物中的用途。药理试验表明，本发明的衍生物具有较好的抗精神分裂症作用，毒性较小。所述衍生物是具有以下通式的化合物的游离碱或盐。