1,1,1,3,3,3-Hexafluoro-2-(2-(4-(3-fluorophenyl)piperidin-1-yl)thiazol-5-yl)propan-2-ol | 1254948-78-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1,1,1,3,3,3-Hexafluoro-2-(2-(4-(3-fluorophenyl)piperidin-1-yl)thiazol-5-yl)propan-2-ol
• 英文别名: 1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
• CAS: 1254948-78-1
• 化学式: C₁₇H₁₅F₇N₂OS
• 分子量: 428.374
• InChiKey: FYPIGNKEJXFGSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  2-(2-bromothiazol-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol 、 4-(3-氟苯基)哌啶 在 三乙胺 作用下， 以 二甲基亚砜 为溶剂， 生成 1,1,1,3,3,3-Hexafluoro-2-(2-(4-(3-fluorophenyl)piperidin-1-yl)thiazol-5-yl)propan-2-ol
  参考文献：
  名称：

  Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

  摘要：

  A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2010.08.047

文献信息

• Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities
  作者：Haifeng Tang、Yan Yan、Zhe Feng、Reynalda K. de Jesus、Lihu Yang、Dorothy A. Levorse、Karen A. Owens、Taro E. Akiyama、Raynald Bergeron、Gino A. Castriota、Thomas W. Doebber、Kenneth P. Ellsworth、Michael E. Lassman、Cai Li、Margaret S. Wu、Bei B. Zhang、Kevin T. Chapman、Sander G. Mills、Joel P. Berger、Alexander Pasternak

  DOI：10.1016/j.bmcl.2010.08.047

  日期：2010.10

  A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes. Published by Elsevier Ltd.