1-hydroxy-2,2,6,6-tetramethyl-4-hydroxypiperidinium chloride | 4972-11-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-hydroxy-2,2,6,6-tetramethyl-4-hydroxypiperidinium chloride
• 英文别名: 1-Hydroxy-2,2,6,6-tetramethyl-4-hydroxypiperidinium Chloride；1-hydroxy-2,2,6,6-tetramethylpiperidin-1-ium-4-ol;chloride
• CAS: 4972-11-6
• 化学式: C₉H₁₉NO₂*ClH
• 分子量: 209.716
• InChiKey: QCJDXHSSMDQRBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.81
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  阻聚剂701 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以65%的产率得到1-hydroxy-2,2,6,6-tetramethyl-4-hydroxypiperidinium chloride
  参考文献：
  名称：

  Studies of Structure−Activity Relationship of Nitroxide Free Radicals and Their Precursors as Modifiers Against Oxidative Damage

  摘要：

  The protective effects of stable nitroxides, as well as their hydroxylamine and amine precursors, have been tested in Chinese hamster V79 cells subjected to H2O2 exposure at fixed concentration or exposure to ionizing radiation. Cytotoxicity was evaluated by monitoring the viability of the cells assessed by the clonogenic assay. The compounds tested at fixed concentration varied in terms of ring size, oxidation state, and ring substituents. Electrochemical studies were carried out to measure the redox midpoint potentials. The studies show that in the case of protection against H2O2 exposure, the protection was determined by the ring size, oxidation state, and redox midpoint potentials. In general the protection factors followed the order nitroxides > hydroxylamines > amines. Both the six-membered ring nitroxides and substituted five-membered ring nitroxides were efficient protectors. For six-membered ring nitroxides, the compounds exhibiting the lowest midpoint potentials exhibited maximal protection. In the case of X-radiation, nitroxides were the most protective though some hydroxylamines were also efficient. The amines were in some cases found to sensitize the toxicity of aerobic radiation exposure. The protection observed by the nitroxides was not dependent on the ring size. However, the ring substituents had significant influence on the protection. Compounds containing a basic side chain were found to provide enhanced protection. The results in this study suggest that these compounds are novel antioxidants which can provide cytoprotection in mammalian cells against diverse types of oxidative insult and identify structural determinants optimal for protection against individual types of damage.

  DOI：

  10.1021/jm9802160

文献信息

• Ink jet ink and recording material
  申请人：——

  公开号：US20040126510A1

  公开（公告）日：2004-07-01

  The present invention relates to an ink jet ink, an ink jet recording material or an ink jet system comprising at least one sterically hindered N-hydroxylamine strong acid salt, for example 1-hydroxy-2,2,6,6-tetramethyl-4-hydroxypiperidinium chloride or bis(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)sebacate dihydrochloride; or comprising at least one dialkyl N-hydroxylamine salt, for example chloride, bisulfate, sulfate, phosphate, nitrate, ascorbate, formate, acetate, benzoate, oxalate, citrate, a carboxylate of ethylenediaminetetraacetic acid or of diethylenetriaminepentaacetic acid or polyacrylate salts of N,N-diethylhydroxylamine, N,N-bis(2-hydroxypropyl)hydroxylamine, N,N-bis(3-hydroxypropyl)hydroxylamine, N,N-dibenzylhydroxylamine or the N,N-di(alkyl)hydroxylamine produced by the direct oxidation of N,N-di(hydrogenated tallow)amine.

  本发明涉及一种喷墨墨水、喷墨记录材料或喷墨系统，其包含至少一种立体位阻的N-羟胺强酸盐，例如1-羟基-2,2,6,6-四甲基-4-羟基哌啶盐酸盐或双(1-羟基-2,2,6,6-四甲基哌啶-4-基)癸二酸二盐酸盐；或包含至少一种双烷基N-羟胺盐，例如氯化物、硫酸氢盐、硫酸盐、磷酸盐、硝酸盐、抗坏血酸盐、甲酸盐、乙酸盐、苯甲酸盐、草酸盐、柠檬酸盐、乙二胺四乙酸或二乙三胺五乙酸的羧酸盐或N,N-二乙基羟胺、N,N-双(2-羟基丙基)羟胺、N,N-双(3-羟基丙基)羟胺、N,N-二苄基羟胺或通过N,N-二(氢化牛脂)胺的直接氧化产生的N,N-二(烷基)羟胺。
• Inhibition of pulp and paper yellowing using nitroxides, hydroxylamines and other coadditives
  申请人：——

  公开号：US20020124980A1

  公开（公告）日：2002-09-12

  Pulps or papers, especially chemimechanical or thermomechanical pulps or papers, which still contain lignin, have enhanced resistance to yellowing when they contain an effective stabilizing amount of a hindered amine compound which preferably is a nitroxide, a hydroxylamine or an ammonium salt thereof. This performance is often further enhanced by the presence of one or more coadditives selected from the group consisting of the UV absorbers, the polymeric inhibitors, the nitrones, the fluorescent whitening agents, metal chelating agents, sulfur containing stabilizers, metal salts and diene compounds. Combinations of nitroxides, hydroxylamines or their salts, benzotriazole or benzophenone UV absorbers and a metal chelating agent are particularly effective. Selected derivatives of 1-oxyl-2,2,6,6-tetramethyl-piperidin-4-ol and selected hydroxylamine salts are novel compounds and are surprisingly effective for this purpose.

  含有木质素的纸浆或纸张，特别是化学机械或热机械纸浆或纸张，如果它们含有有效的阻化胺化合物（最好是亚硝基自由基，羟胺或其铵盐），则具有增强的抗黄变性能。当与来自紫外线吸收剂、聚合抑制剂、亚硝基醇、荧光增白剂、金属螯合剂、含硫稳定剂、金属盐和二烯化合物等组成的一种或多种协同添加剂一起使用时，通常可以进一步提高其性能。亚硝基自由基、羟胺或其盐、苯并三唑或苯并酚类紫外线吸收剂和金属螯合剂的组合尤其有效。选择的1-氧基-2,2,6,6-四甲基哌啶-4-醇和选择的羟胺盐衍生物是新的化合物，出乎意料地有效。
• Stabilization of wood substrates
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP0943665A1

  公开（公告）日：1999-09-22

  The invention relates to a method of protecting wood against light-induced degradation by treatment with    a stain or impregnation which penetrates the surface of the wood comprising a) at least one organic solvent; b) a hindered amine compound of formula I or II where G1 and G2 are independently alkyl of 1 to 4 carbon atoms or are together pentamethylene, Z1 and Z2 are each methyl, or Z1 and Z2 together form a linking moiety which may additionally be substituted by an ester, ether, hydroxy, oxo, cyanohydrin, amide, amino, carboxy or urethane group, E is oxyl or hydroxyl, X is an inorganic or organic anion, and where the total charge of cations h is equal to the total charge of anions j.

  本发明涉及一种保护木材免受光引起的降解的方法，其处理方法为 渗入木材表面的染色剂或浸渍剂，包括 a) 至少一种有机溶剂 b) 式 I 或 II 的受阻胺化合物 其中 G1 和 G2 独立地为 1 至 4 个碳原子的烷基，或共同为五亚甲基、 Z1和Z2各自为甲基，或Z1和Z2共同形成一个连接基团，该连接基团可另外被酯、醚、羟基、氧代、氰基、酰胺、氨基、羧基或聚氨酯基团取代、 E 是氧基或羟基、 X 是无机或有机阴离子，以及 其中阳离子的总电荷 h 等于阴离子的总电荷 j。
• Anti-radical agents
  申请人：Baschong Werner

  公开号：US10098849B2

  公开（公告）日：2018-10-16

  Compounds of the formulae and selected hindered nitroxyl, hydroxylamine and hydroxylamine salt compounds such as the compound of the formula wherein G1 is hydrogen; C1-C22alkyl; C1-C22alkylthio; C2-C22alkylthioalkyl; C5-C7cycloalkyl; phenyl; C7-C9-phenylalkyl; or SO3M; G2 is C1-C22alkyl; C5-C7cycloalkyl; phenyl; or C7-C9-phenylalkyl; E is oxyl or hydroxyl; V is —O—; or —NH—; a is 0 or 1 or 2; b, c and d and g are each independently of one another 0 or 1; e is an integer from 1 to 4; f, m, n and p are each independently of one another an integer from 1 to 3; q is 0 or an integer from 1 to 3; Q, T and G3 are as defined in claim 1; G4 and G5 are each independently of the other hydrogen; or C1-C22alkyl; exhibit marked antiinflammatory action.

  式中的化合物 和选定的受阻硝基、羟胺和羟胺盐化合物，如式 其中 G1 是氢；C1-C22烷基；C1-C22烷硫基；C2-C22烷硫基；C5-C7 环烷基；苯基；C7-C9-苯基烷基；或 SO3M；G2 是 C1-C22烷基；C5-C7 环烷基；苯基；或 C7-C9-苯基烷基；E 是氧或羟基；V 是-O-；或-NH-；a 是 0 或 1 或 2； b、c 和 d 和 g 各自独立地为 0 或 1； e 是 1 至 4 的整数； f、m、n 和 p 各自独立地为 1 至 3 的整数； q 为 0 或 1 至 3 的整数； Q、T 和 G3 如权利要求 1 所定义； G4和G5各自独立地为氢；或C1-C22烷基； 具有明显的抗炎作用。
• Process for the staining of wood with aqueous wood stains
  申请人：——

  公开号：US20020000011A1

  公开（公告）日：2002-01-03

  The present invention relates to a process for the staining of wood, which comprises treating the unstained wood with an aqueous preparation comprising a) at least one dye, and b) at least one dye stabilizer of the formula (I) or (II) 1 in which G 1 and G 2 , independently of one another, are C 1 —C 4 alkyl or together are pentamethylene, Z 1 and Z 2 are methyl, or Z 1 and Z 2 form a bridging member which is unsubstituted or substituted by an ester, ether, hydroxyl, oxo, cyanohydrin, amido, amino, carboxyl or urethane radical, E is oxyl or hydroxyl, and X is an inorganic or organic anion, and the total number of cations h corresponds to the total number of anions j, to a wood stain comprising a dye and a dye stabilizer of the formula (I) or (II), and to the use of this wood stain for the staining of wood.

  本发明涉及一种木材染色工艺，包括用一种水性制剂处理未染色的木材，该制剂包括 a) 至少一种染料，和 b) 至少一种式 (I) 或 (II) 的染料稳定剂 1 其中 G 1 和 G 2 互不影响，分别为 C 1 -C 4 烷基或共同为五亚甲基，Z 1 和 Z 2 为甲基，或 Z 1 和 Z 2 形成未被取代或被酯、醚、羟基、氧代、氰基、氨基、氨基、羧基或聚氨酯基取代的桥接构件，E 是氧代或羟基，X 是无机或有机阴离子、以及阳离子的总数 h 与阴离子的总数 j 相对应的木材染色剂，包括式 (I) 或 (II) 的染料和染料稳定剂，以及该木材染色剂用于木材染色的用途。