Indole derivatives for the treatment of depression and anxiety
申请人:——
公开号:US20040006229A1
公开(公告)日:2004-01-08
The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
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The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
1
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1
作者:Kumiko Takeuchi、Todd J Kohn、Nicholas A Honigschmidt、Vincent P Rocco、Patrick G Spinazze、Daniel J Koch、David L Nelson、D.Bradley Wainscott、Laura J Ahmad、Janice Shaw、Penny G Threlkeld、David T Wong
DOI:10.1016/s0960-894x(03)00303-2
日期:2003.6
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. 1-(4H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high affinity at the 5-HT1A receptor and serotonin reuptake inhibition at nanomolar concentrations for dual activities. (C) 2003 Elsevier Science Ltd. All rights reserved.