N-(1,2,2,6,6-五甲基-4-哌啶亚基)羟胺 | 6636-23-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: N-(1,2,2,6,6-五甲基-4-哌啶亚基)羟胺
• 英文名称: 4-Hydroximino-1,2,2,6,6-pentamethyl-piperidin
• 英文别名: 1,2,2,6,6-pentamethyl-piperidin-4-one oxime；1,2,2,6,6-Pentamethyl-piperidin-4-on-oxim；N-(1,2,2,6,6-pentamethylpiperidin-4-ylidene)hydroxylamine
• CAS: 6636-23-3
• 化学式: C₁₀H₂₀N₂O
• 分子量: 184.282
• InChiKey: FRVVZVCAWWGTOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  N-(1,2,2,6,6-五甲基-4-哌啶亚基)羟胺 在 苯甲醛 作用下， 以2.3 g (30%)的产率得到alpha-Phenyl-N-(1,2,2,6,6-pentamethylpiperidin-4-yl) nitrone
  参考文献：
  名称：

  Polymer stabilizers containing both hindered amine and nitrone moieties

  摘要：

  公开号：

  EP0413665B1
• 作为产物：
  描述：

  1,2,2,6,6-五甲基-4-哌啶酮 、 盐酸羟胺 生成 N-(1,2,2,6,6-五甲基-4-哌啶亚基)羟胺
  参考文献：
  名称：

  NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF

  摘要：

  本发明涉及包括羧酸和磷酸酯在内的亚硝基衍生物，其在生理条件下捐赠亚硝基（HNO）化合物。本发明的化合物和组合物在治疗和/或预防对亚硝基治疗有反应的疾病或病症的发生和/或发展方面有用，包括心力衰竭、缺血/再灌注损伤和癌症。

  公开号：

  US20090281062A1

文献信息

• Indole derivatives for the treatment of osteoporosis
  申请人：Smith Kline Beecham SpA

  公开号：US20020173659A1

  公开（公告）日：2002-11-21

  A compound of formula (I): 1 or a salt thereof, or a solvate thereof, wherein Ra represents a group R 5 which is hydrogen, alkyl or optionally substituted aryl and Rb represents a moiety of formula (a): 2 wherein X represents a hydroxy or an alkoxy group wherein the alkyl group may be substituted or unsubstituted or X represents a group NR s R t wherein R s and R t each independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or R s and R t together with the nitrogen to which they are attached form a heterocyclic group; RI represents an alkyl or a substituted or unsubstituted aryl group; and R 2 , R 3 and R 4 each independently represent hydrogen, alkyl, aryl or substituted aryl R 6 and R 7 each independently represents hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R 6 and R 7 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; and R 8 represents hydrogen, hydroxy, alkanoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxyalkyl, carbalkoxyalkyl, carbamoyl or aminosulphonyl; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine

  式（I）的化合物：1或其盐，或其溶剂化物，其中Ra代表一个R5基团，该基团是氢，烷基或可选取代芳基，Rb代表式（a）的一个基团：2其中X代表羟基或烷氧基，其中烷基可能是取代或未取代的，或者X代表羰基-NRsRt，其中Rs和Rt各自独立地代表氢，烷基，取代烷基，可选取代烯基，可选取代芳基，可选取代芳基烷基，可选取代杂环基或可选取代杂环基烷基，或Rs和Rt与它们所连接的氮一起形成杂环基；RI代表烷基或取代或未取代的芳基基团；R2、R3和R4各自独立地代表氢，烷基，芳基或取代芳基；R6和R7各自独立地代表氢，羟基，氨基，烷氧基，可选取代芳氧基，可选取代苯甲氧基，烷基氨基，二烷基氨基，卤素，三氟甲基，三氟甲氧基，硝基，烷基，羧基，羰基氧基，氨基甲酰基，烷基氨甲酰基，或R6和R7一起代表亚甲二氧基，羰基二氧基或羰基二氨基；以及R8代表氢，羟基，烷酰基，烷基，氨基烷基，羟基烷基，羧基烷基，羰基氧基烷基，氨甲酰基或氨基磺酰基；一种制备这样的化合物的方法，包含这样的化合物的制药组合物以及这样的化合物在医学上的用途。
• Polymer stabilizers containing both hindered amine and hydroxlamine
  申请人：Ciba-Geigy Corporation

  公开号：US05410047A1

  公开（公告）日：1995-04-25

  Compounds possessing both a hindered amine moiety, such as a derivative of 2,2,6,6-tetramethylpiperidine, and a hydroxylamine moiety where the N-hydroxy group is not attached to a nitrogen atom in a piperidine ring are valuable stabilizers for protecting polymer compositions against the deleterious effects of actinic light and from the adverse effects of high temperature polymer processing environments.

  同时具有受阻胺基团（如2,2,6,6-四甲基哌啶衍生物）和羟肟基团的化合物，其中N-羟基基团未附着在哌啶环中的氮原子上，对于保护聚合物组合物免受光化学反应和高温聚合物加工环境的不利影响是有价值的稳定剂。
• Polymer stabilizers containing both hindered amine and hydroxylamine
  申请人：Ciba-Geigy Corporation

  公开号：US05202441A1

  公开（公告）日：1993-04-13

  Compounds possessing both a hindered amine moiety, such as a derivative of 2,2,6,6-tetramethylpiperidine, and a hydroxylamine moiety where the N-hydroxy group is not attached to a nitrogen atom in a piperidine ring are valuable stabilizers for protecting polymer compositions against the deleterious effects of actinic light and from the adverse effects of high temperature polymer processing environments.

  同时具有受阻胺基团和羟胺基团的化合物，例如2,2,6,6-四甲基哌啶衍生物，并且N-羟基团未连接到哌啶环中的氮原子，对于保护聚合物组分免受光化学影响和高温聚合物加工环境的不良影响具有重要的稳定作用。
• Nitroso compounds as nitroxyl donors and methods of use thereof
  申请人：Cardioxyl Pharmaceuticals, Inc.

  公开号：US08318705B2

  公开（公告）日：2012-11-27

  The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.

  本发明涉及一种亚硝基衍生物，包括羧酸和磷酸酯化的羟基亚硝基化合物，在生理条件下捐赠亚硝基（HNO）。本发明的化合物和组合物在治疗和/或预防对亚硝基治疗有反应的疾病或病状的发生和/或发展方面有用，包括心衰、缺血/再灌注损伤和癌症。
• Novel Nitroso Compounds as Nitroxyl Donors and Methods of Use Thereof
  申请人：CARDIOXYL PHARMACEUTICALS, INC.

  公开号：US20130045951A1

  公开（公告）日：2013-02-21

  The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.

  本发明涉及一种亚硝基衍生物，包括羧酸和磷酸酯的羟基亚硝基化合物，可在生理条件下捐赠亚硝基（HNO）。该发明的化合物和组合物在治疗和/或预防对亚硝基疗法有反应的疾病或状况的发生和/或发展方面是有用的，包括心衰、缺血/再灌注损伤和癌症。