5-methyl-2,3-dihydro-1H-pyrrolizine | 7312-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯嗪
• 英文名称: 5-methyl-2,3-dihydro-1H-pyrrolizine
• 英文别名: dihydro-6-methyl-1H-pyrrolo[1,2-a]pyrrole；2,3-Dihydro-5-methyl-1H-pyrrolizin
• CAS: 7312-34-7
• 化学式: C₈H₁₁N
• 分子量: 121.182
• InChiKey: SSUANKSPZQHRRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  5-(but-3-ynyl)-3,4-dihydro-2H-pyrrole 在 silver trifluoromethanesulfonate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 1.5h， 以64%的产率得到5-methyl-2,3-dihydro-1H-pyrrolizine
  参考文献：
  名称：

  Pyrrole Synthesis Catalyzed by AgOTf or Cationic Au(I) Complexes

  摘要：

  Either silver trifluoromethanesulfonate or a mixture of gold( I) chloride, silver trifluoromethanesulfonate, and triphenylphosphine catalyze the formation of pyrroles from substituted beta-alkynyl ketones and amines. The reactions proceed by using 5 mol % of catalyst with yields of isolated pyrroles ranging from 13% to 92%. Sixteen examples are used to compare the effectiveness of each catalyst.

  DOI：

  10.1021/jo060382c

文献信息

• Simple method for the synthesis of 1,2-dihydropyrrolizines
  作者：I. M. Skvortsov、N. A. Buntyakova、M. I. Kuramshin、S. A. Filimonov

  DOI：10.1007/bf00505779

  日期：1983.10
• SKVORTSOV, I. M.;BUNTYAKOVA, N. A.;KURAMSHIN, M. I.;FILIMONOV, XIMIYA GETEROTSIKL. SOEDIN., 1983, N 10, 1424-1425
  作者：SKVORTSOV, I. M.、BUNTYAKOVA, N. A.、KURAMSHIN, M. I.、FILIMONOV

  DOI：——

  日期：——
• Reaction of N-Acylated Isofebrifugine with Acid
  作者：Yasuo Takeuchi、Kumiko Azuma、Hitoshi Abe、Takashi Harayama

  DOI：10.3987/com-00-8991

  日期：——

  The reaction of N-acylated isofebrifugine with hydrochloric acid is discussed. Although the corresponding deprotected compound was not isolated, three new heterocyclic compounds were obtained. Based on these findings, new furan and pyrrole derivatives were prepared.
• SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE
  申请人：CS Pharmatech Limited

  公开号：EP3399968B1

  公开（公告）日：2021-10-20
• Pyrrole Synthesis Catalyzed by AgOTf or Cationic Au(I) Complexes
  作者：Tyler J. Harrison、Jennifer A. Kozak、Montserrat Corbella-Pané、Gregory R. Dake

  DOI：10.1021/jo060382c

  日期：2006.6.1

  Either silver trifluoromethanesulfonate or a mixture of gold( I) chloride, silver trifluoromethanesulfonate, and triphenylphosphine catalyze the formation of pyrroles from substituted beta-alkynyl ketones and amines. The reactions proceed by using 5 mol % of catalyst with yields of isolated pyrroles ranging from 13% to 92%. Sixteen examples are used to compare the effectiveness of each catalyst.