Benzyl cyano[3-(4-methylpiperazin-1-yl)quinoxalin-2-yl]acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Benzyl cyano[3-(4-methylpiperazin-1-yl)quinoxalin-2-yl]acetate
• 英文别名: benzyl 2-cyano-2-[3-(4-methylpiperazin-1-yl)quinoxalin-2-yl]acetate
• 化学式: C₂₃H₂₃N₅O₂
• 分子量: 401.5
• InChiKey: CWRKXFYNYPBFFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  82.4
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING CANCERS<br/>[FR] COMPOSÉS ET MÉTHODES UTILES POUR LE TRAITEMENT OU LA PRÉVENTION DE CANCERS
  申请人：CORSELLO STEVEN M

  公开号：WO2018183936A1

  公开（公告）日：2018-10-04

  The present invention includes CSNK1A1 inhibitors that are useful in treating or preventing a cancer in a subject. In certain embodiments, the cancer comprises a hematological cancer, such as but not limited to acute myeloid leukemia (AML) and/or MDS (myelodysplastic syndrome, including 5q-MDS). In other embodiments, the cancer comprises colon cancer.

  本发明涉及CSNK1A1抑制剂，可用于治疗或预防受试者中的癌症。在某些实施例中，癌症包括血液系统癌症，如但不限于急性髓系白血病（AML）和/或MDS（髓增生异常综合征，包括5q-MDS）。在其他实施例中，癌症包括结肠癌。
• COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING CANCERS
  申请人：THE BROAD INSTITUTE, INC.

  公开号：US20220096513A1

  公开（公告）日：2022-03-31

  The present invention includes CSNK1A1 inhibitors that are useful in treating or preventing a cancer in a subject. In certain embodiments, the cancer comprises a hematological cancer, such as but not limited to acute myeloid leukemia (AML) and/or MDS (myelodysplastic syndrome, including 5q-MDS). In other embodiments, the cancer comprises colon cancer.