(2R,3S)-3-[1-(tert-Butyl-dimethyl-silanyl)-7-methoxy-1H-indol-4-yl]-1-trityloxy-butan-2-ol | 436091-70-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (2R,3S)-3-[1-(tert-Butyl-dimethyl-silanyl)-7-methoxy-1H-indol-4-yl]-1-trityloxy-butan-2-ol
• 英文别名: (2R,3S)-3-[1-[tert-butyl(dimethyl)silyl]-7-methoxyindol-4-yl]-1-trityloxybutan-2-ol
• CAS: 436091-70-2
• 化学式: C₃₈H₄₅NO₃Si
• 分子量: 591.866
• InChiKey: QUIPJLJEUPXAHZ-GVYVVWIYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.98
• 重原子数：
  43
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  43.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2R,3S)-3-[1-(tert-Butyl-dimethyl-silanyl)-7-methoxy-1H-indol-4-yl]-1-trityloxy-butan-2-ol 在 四丁基氟化铵 、 sodium hydride 作用下， 生成 (2R,3S)-3-[7-Methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-1-trityloxy-butan-2-ol
  参考文献：
  名称：

  Enantioselective synthesis of the aminoimidazole segment of dragmacidin D

  摘要：

  A facile enantioselective synthesis of the 2-aminoimidazole side-chain of dragmacidin D has been developed. which involved the regio- and stereoselective opening of the chiral epoxide 9 by a diindolylcuprate reagent, followed by further steps to give 5-substituted N-(1H-imidazol-2-yl)acetamide 2. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02331-0
• 作为产物：
  描述：

  4-溴-7-甲氧基吲哚 在 正丁基锂 、 三氟化硼乙醚 作用下， 以 四氢呋喃 为溶剂， 生成 (2R,3S)-3-[1-(tert-Butyl-dimethyl-silanyl)-7-methoxy-1H-indol-4-yl]-1-trityloxy-butan-2-ol
  参考文献：
  名称：

  Enantioselective synthesis of the aminoimidazole segment of dragmacidin D

  摘要：

  A facile enantioselective synthesis of the 2-aminoimidazole side-chain of dragmacidin D has been developed. which involved the regio- and stereoselective opening of the chiral epoxide 9 by a diindolylcuprate reagent, followed by further steps to give 5-substituted N-(1H-imidazol-2-yl)acetamide 2. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02331-0

文献信息

• Enantioselective synthesis of the aminoimidazole segment of dragmacidin D
  作者：Cai-Guang Yang、Jun Wang、Biao Jiang

  DOI：10.1016/s0040-4039(01)02331-0

  日期：2002.2

  A facile enantioselective synthesis of the 2-aminoimidazole side-chain of dragmacidin D has been developed. which involved the regio- and stereoselective opening of the chiral epoxide 9 by a diindolylcuprate reagent, followed by further steps to give 5-substituted N-(1H-imidazol-2-yl)acetamide 2. (C) 2002 Elsevier Science Ltd. All rights reserved.