1-(Methylamino)-3-(4-methylpiperazin-1-yl)propan-2-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(Methylamino)-3-(4-methylpiperazin-1-yl)propan-2-ol
• 化学式: C₉H₂₁N₃O
• mdl: MFCD00776867
• 分子量: 187.28
• InChiKey: VCDXYRUOTHQYNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Polyurethane catalyst and application thereof
  申请人：JIANGSU OSIC PERFORMANCE MATERIALS CO. LTD.

  公开号：US10889681B2

  公开（公告）日：2021-01-12

  A polyurethane catalyst comprises a sodium compound, the sodium compound being 1 to 60 wt % of the polyurethane catalyst by the mass percent, and further comprises a tertiary amine and/or pyridine compound. The sodium compound and the tertiary amine and/or pyridine compound achieve a synergistic effect; during the catalysis of the polymerization of isocyanate and polyalcohol, the speed of the polymerization reaction is increased; and the prepared polyurethane material has excellent physical properties, does not contain any heavy metal element at all, is an environment-friendly catalyst, solves the technical problem of ensuring environmental protection, safety and the catalytic efficiency of the polyurethane catalyst, and is particularly applicable to the preparation of polyurethane synthetic leather resin slurry, a polyurethane elastomer (prepolymer), a polyurethane coating, a polyurethane adhesive, a polyurethane composite material, flexible polyurethane foam, and a rigid polyurethane material.

  一种聚氨酯催化剂包括钠化合物，钠化合物占聚氨酯催化剂的质量百分比为 1 至 60 wt%，还包括叔胺和/或吡啶化合物。钠化合物和叔胺和/或吡啶化合物具有协同效应；在催化异氰酸酯和多元醇聚合的过程中，聚合反应的速度得到提高；本发明制备的聚氨酯材料物理性能优异，不含任何重金属元素，属于环境友好型催化剂，解决了确保聚氨酯催化剂环保、安全和催化效率的技术难题，特别适用于制备聚氨酯合成革树脂浆料、聚氨酯弹性体（预聚物）、聚氨酯涂料、聚氨酯胶粘剂、聚氨酯复合材料、软质聚氨酯泡沫塑料和硬质聚氨酯材料。
• EP1610773A2
  申请人：——

  公开号：EP1610773A2

  公开（公告）日：2006-01-04
• METHODS AND COMPOSITIONS FOR TREATING OPHTHALMIC CONDITIONS VIA MODULATION OF MEGALIN ACTIVITY
  申请人：Sirion Therapeutics, Inc.

  公开号：EP2037951A2

  公开（公告）日：2009-03-25
• POLYURETHANE CATALYST AND APPLICATION THEREOF
  申请人：Jiangsu Osic Performance Materials Co. Ltd.

  公开号：EP3241856B1

  公开（公告）日：2021-08-18
• Use of compounds for the prevention of drug-induced cell toxicity
  申请人：Nykjaer Anders

  公开号：US20070004727A1

  公开（公告）日：2007-01-04

  The present invention relates to the use of compounds for the manufacture of a medicament for the prophylaxis and/or treatment of induced cell toxicity, such as nephrotoxicity and ototoxicity, in particular where the cell toxicity is induced by a medical treatment. In a preferred embodiment the compounds have at least two nitrogen atoms, more preferably at least two amino groups. The compounds according to the invention are capable of blocking binding of cell toxic compounds to the megalin receptor, and thereby inhibiting uptake of the cell toxic compounds into cells. The invention further relates to novel compounds for use in said treatment, as well as a method for reducing the cell toxicity of cell toxic compounds.