N-(2-羟乙基)哌嗪-N'-4-丁磺酸

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: N-(2-羟乙基)哌嗪-N'-4-丁磺酸
• 中文别名: N-(2-羟乙基)哌嗪-N'-(4-丁磺酸)
• 英文名称: 4-[4-(2-hydroxyethyl)piperazin-1-ium-1-yl]butane-1-sulfonate
• 化学式: C10H22N2O4S
• 分子量: 266.36
• InChiKey: LOJNFONOHINEFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  89.5
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] FORMULATION OF ANTIBODY-DRUG CONJUGATE<br/>[FR] FORMULATION DE CONJUGUÉ ANTICORPS-MÉDICAMENT
  申请人：SEAGEN INC

  公开号：WO2021067820A1

  公开（公告）日：2021-04-08

  The present disclosure relates to formulations of antibody-drug conjugates (ADCs) and methods of preparation and use thereof.

  本公开涉及抗体药物偶联物（ADCs）的配方以及其制备和使用方法。
• [EN] PROCESSES FOR PREPARING ACC INHIBITORS AND SOLID FORMS THEREOF<br/>[FR] PROCÉDÉS DE PRÉPARATION D'INHIBITEURS D'ACC ET FORMES SOLIDES CORRESPONDANTES
  申请人：GILEAD SCIENCES INC

  公开号：WO2018161022A1

  公开（公告）日：2018-09-07

  The present disclosure provides solid forms, including a salt or co-crystal, of Compound I which exhibits Acetyl-CoA carboxylase ("ACC") inhibitory activity and may be useful in treating ACC mediated diseases. Also provided herein are processes or steps for the preparation of a Compound I and intermediates useful for the processes or steps described herein.

  本公开提供了化合物I的固体形式，包括盐或共晶，该化合物表现出乙酰辅酶A羧化酶（"ACC"）抑制活性，并可能在治疗ACC介导的疾病中有用。本文还提供了用于制备化合物I的过程或步骤，以及对所述过程或步骤有用的中间体。
• NOVEL PYRIDINE CARBOXYLIC ACID BASED COMPOUND USED AS A P2X1 AND P2X3 RECEPTOR ANTAGONIST, A PRODUCTION METHOD FOR THE SAME AND A COMPOSITION COMPRISING THE SAME
  申请人：Kim Yong-Chul

  公开号：US20130040997A1

  公开（公告）日：2013-02-14

  Provided are a novel pyridine carboxylic acid based compound used as a P2X 1 and P2X 3 receptor antagonist, a production method for the same and a composition comprising the same. The compound according to the present invention is a powerful antagonist of P2X 1 and P2X 3 receptors, and hence can be used as a drug for treating or preventing diseases involving neurological pain or chronic inflammatory diseases which are diseases caused by P2X 1 and P2X 3 receptor activity.

  提供了一种基于吡啶羧酸的新型化合物，用作P2X1和P2X3受体拮抗剂，以及该化合物的生产方法和包含该化合物的组合物。根据本发明的化合物是P2X1和P2X3受体的强效拮抗剂，因此可用作治疗或预防涉及神经疼痛或慢性炎症疾病的药物，这些疾病是由P2X1和P2X3受体活性引起的疾病。
• [EN] BLOCK COPOLYMER COMPLEX COACERVATE CORE MICELLES FOR ENZYMATIC CATALYSIS IN ORGANIC SOLVENT<br/>[FR] MICELLES À NOYAU DE COACERVAT COMPLEXE À COPOLYMÈRE BLOC POUR LA CATALYSE ENZYMATIQUE DANS UN SOLVANT ORGANIQUE
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2016044400A1

  公开（公告）日：2016-03-24

  Disclosed are complex coacervate core micelles comprising an enzyme capable of hydrolyzing organophosphorous compounds, such as nerve agents, and, for example, their use in remediation or decontamination of stockpiles of chemical weapons.

  本发明涉及一种复合凝胶核心胶束，其中包括一种能够水解有机磷化合物（如神经毒剂）的酶，例如，它们可用于清除或去污化学武器储备。
• Bronchodilating compositions and methods
  申请人：Dey L.P.

  公开号：US20020151597A1

  公开（公告）日：2002-10-17

  Bronchodilating compositions and methods are provided. The compositions are intended for administration as a nebulized aerosol. In certain embodiments, the compositions contain formoterol, or a derivative thereof. Methods for treatment, prevention, or amelioration of one or more symptoms of bronchoconstrictive disorders using the compositions provided herein are also provided.

  提供支气管扩张剂组合物和方法。这些组合物旨在作为雾化气溶胶进行管理。在某些实施例中，这些组合物含有福莫特罗或其衍生物。还提供使用此处提供的组合物治疗、预防或改善支气管收缩性疾病的一个或多个症状的方法。