3-(4-propan-2-ylpiperazin-1-yl)propanoic Acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-(4-propan-2-ylpiperazin-1-yl)propanoic Acid
• 化学式: C₁₀H₂₀N₂O₂
• 分子量: 200.28
• InChiKey: DRSLDFAOCUJVLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Benzofuran Derivatives
  申请人：Kawaguchi Takayuki

  公开号：US20090209511A1

  公开（公告）日：2009-08-20

  The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: —N═ or —CH═; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or an optionally substituted saturated heterocyclic group; A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; R 1 is a hydrogen atom or a halogen atom; Ring B is an optionally substituted benzene ring; and R 3 is a hydrogen atom, or a pharmaceutically acceptable salt thereof, which is useful as a medicament, especially as an activated blood coagulation factor X inhibitor.

  本发明提供了式[1]的苯并呋喃衍生物：其中x是式：—N═或—CH═的基团；Y是可选取代的氨基基团、可选取代的环烷基团或可选取代的饱和杂环基团；A是单键、具有双键的碳链（可在链的内部或端部）或氧原子；R1是氢原子或卤原子；环B是可选取代的苯环；R3是氢原子或其药学上可接受的盐，其作为药物特别是作为激活的血凝因子X抑制剂有用。
• [EN] ANTI-VIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：INFEX THERAPEUTICS LTD

  公开号：WO2022189810A1

  公开（公告）日：2022-09-15

  This invention relates to compounds that can be used to treat viral infections. The compounds are papain-like protease (PLpro) inhibitors.

  本发明涉及可用于治疗病毒感染的化合物。这些化合物是木瓜蛋白酶类似物酶（PLpro）抑制剂。
• Pyrimido-pyridazinone compounds and methods of use thereof
  申请人：Asana Biosciences, LLC

  公开号：US10183944B2

  公开（公告）日：2019-01-22

  The present application provides novel pyrimido-pyridazinone compounds and methods for preparing and using these compounds. These compounds are useful in treating inflammation in patients by administering one or more of the compounds to a patient. In one embodiment, the novel pyrimido-pyridazinone compound is of Formula (I) and R1 and R2 are defined herein.

  本申请提供了新型嘧啶哒嗪酮化合物以及制备和使用这些化合物的方法。通过向患者施用一种或多种化合物，这些化合物可用于治疗患者的炎症。在一个实施方案中，新型嘧啶基哒嗪酮化合物为式(I)，R1和R2在此定义。
• Compounds that inhibit MCL-1 protein
  申请人：AMGEN INC.

  公开号：US10300075B2

  公开（公告）日：2019-05-28

  Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

  本文提供了髓细胞白血病 1 蛋白（Mcl-1）抑制剂、其制备方法、相关药物组合物以及使用方法。例如，本文提供了式 I 的化合物、 或其立体异构体；以及其药学上可接受的盐类和含有这些化合物的药物组合物。本文提供的化合物和组合物可用于治疗癌症等疾病或病症。
• Spirocycle compounds and methods of making and using same
  申请人：H. Lundbeck A/S

  公开号：US11161856B2

  公开（公告）日：2021-11-02

  Provided herein are compounds of the formula: and compositions comprising the same, which are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

  本文提供的是式中化合物： 以及包含这些化合物的组合物，它们可用作 MAGL 的调节剂。此外，上述化合物和组合物还可用于治疗疼痛。