2-Bromo-5-(piperazin-1-yl)aniline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-Bromo-5-(piperazin-1-yl)aniline
• 英文别名: 2-bromo-5-piperazin-1-ylaniline
• 化学式: C₁₀H₁₄BrN₃
• 分子量: 256.14
• InChiKey: JYJNCPVZYJNUCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  41.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Oxazole derivatives for use in the treatment of cancer
  申请人：LIFEARC

  公开号：US10961233B2

  公开（公告）日：2021-03-30

  A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, • B is a saturated or partially unsaturated monocyclic or bicyclic, heterocyclic group optionally substituted by one or more R 10 groups; *X is selected from SO2, CO2, CO, CONR11 and (CR12R13) p. Said compounds are capable of inhibiting PAICS and are useful in the treatment of proliferative disorders. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula (I).

  本发明的第一个方面涉及式（I）化合物或其药学上可接受的盐或酯，-B是饱和或部分不饱和的单环或双环、杂环基团，任选被一个或多个R 10基团取代；*X选自SO2、CO2、CO、CONR11和(CR12R13)p。其他方面涉及药物组合物、治疗用途和制备式（I）化合物的工艺。
• OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER
  申请人：LIFEARC

  公开号：US20190352295A1

  公开（公告）日：2019-11-21

  A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, • B is a saturated or partially unsaturated monocyclic or bicyclic, heterocyclic group optionally substituted by one or more R 10 groups; * X is selected from SO 2 , CO 2 , CO, CONR 11 and (CR 12 R 13 ) p. Said compounds are capable of inhibiting PAICS and are useful in the treatment of proliferative disorders. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula (I).