2-Methyl-3-[4-[1-(2-pyrimidyl)-4-piperazinyl]butyl]-4-thiazolidinone maleate | 124468-35-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-Methyl-3-[4-[1-(2-pyrimidyl)-4-piperazinyl]butyl]-4-thiazolidinone maleate
• 英文别名: (Z)-but-2-enedioic acid;2-methyl-3-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,3-thiazolidin-4-one
• CAS: 124468-35-5
• 化学式: C₄H₄O₄*C₁₆H₂₅N₅OS
• 分子量: 451.547
• InChiKey: JNTOINWDRKBXTB-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.01
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  153
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  乙醚 、 1-(2-pyrimidyl)piperazine dihydrochloride 、 potassium carbonate 、 3-(4-bromobutyl)-2-methyl-4-thiazolidinone 在 sodium iodide 作用下， 以 乙酸乙酯 、 乙腈 为溶剂， 生成 2-Methyl-3-[4-[1-(2-pyrimidyl)-4-piperazinyl]butyl]-4-thiazolidinone maleate
  参考文献：
  名称：

  3-[4-(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinone compounds

  摘要：

  3-[4-（1-取代-4-哌嗪基）丁基]-4-噻唑烷酮化合物可用作抗精神病药、镇痛药、抗抽搐药和抗焦虑药。

  公开号：

  US04933453A1

文献信息

• 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related
  申请人：Hoechst-Roussel Pharmaceuticals Incorporated

  公开号：US05229388A1

  公开（公告）日：1993-07-20

  There are disclosed compounds of the formula, ##STR1## where n is 0, 1 or 2; A is ##STR2## where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; Y in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; m is 1 or 2; k is 1 or 2; R.sub.1 and R.sub.2 are independently hydrogen, loweralkyl, ##STR3## or aryl except that when R.sub.1 is ##STR4## or aryl, R.sub.2 is hydrogen, or alternatively R.sub.1 +R.sub.2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, indan or piperidine ring; R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl, or alternatively R.sub.3 +R.sub.4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl signifying an unsubstituted phenyl group or a phenyl group substituted with 1, 2 or 3 substituents each of which being independently loweralkyl, loweralkoxy, hydroxy, halogen, loweralkylthio, cyano, amino or trifluoromethyl, which are useful as antipsychotic, analgesic, anticonvulsant and anxiolytic agents.

  公式中披露了化合物，其中n为0、1或2；A为其中X在每次出现时独立地为氢、卤素、较低烷基、羟基、硝基、较低烷氧基、氨基、氰基、三氟甲基或甲硫基；Y在每次出现时独立地为氢、卤素、较低烷基、羟基、硝基、较低烷氧基、氨基、氰基、三氟甲基或甲硫基；m为1或2；k为1或2；R.sub.1和R.sub.2独立地为氢、较低烷基、或芳基，但当R.sub.1为或芳基时，R.sub.2为氢，或者R.sub.1 +R.sub.2与它们附着的碳原子一起形成环戊烷、环己烷、环庚烷、吡喃、硫代吡喃、茚或哌啶环；R.sub.3和R.sub.4独立地为氢或较低烷基，或者R.sub.3 +R.sub.4与它们附着的碳原子一起形成环戊烷、环己烷、环庚烷、吡喃、硫代吡喃、吡咯烷或哌啶环，术语芳基表示未取代的苯基或一个苯基，其上取代基为1、2或3个，每个取代基独立地为较低烷基、较低烷氧基、羟基、卤素、较低烷硫基、氰基、氨基或三氟甲基，这些化合物可用作抗精神病、镇痛、抗癫痫和抗焦虑药物。
• 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0316723A1

  公开（公告）日：1989-05-24

  There are disclosed compounds of the formula, where n is 0̸ or 1; A is where X, Y, Z, U, V, W, Q, S and T are each hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano or trifluoromethyl; m is 1 or 2; R₁ and R₂ are independently hydrogen, loweralkyl or aryl, or alternatively R₁ + R₂ taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring; R₃ and R₄ are independently hydrogen or loweralkyl, or alternatively R₃ + R₄ taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl signifying an unsubstituted phenyl group or a phenyl group substituted with 1, 2 or 3 substituents each of which being independently loweralkyl, loweralkoxy, hydroxy, halogen, loweralkylthio, cyano, amino or trifluormethyl, and a process for their preparation. The compounds are useful as antipsychotic, analgesic, anticonvulsant and anxiolytic agents.

  公开了如下式的化合物 其中 n 是 0̸ 或 1；A 是 其中 X、Y、Z、U、V、W、Q、S 和 T 各为氢、卤素、低级烷基、羟基、硝基、低级烷氧基、氨基、氰基或三氟甲基；m 为 1 或 2；R₁ 和 R₂ 独立地为氢、低级烷基或芳基，或者 R₁ + R₂ 与它们所连接的碳原子一起形成环戊烷、环己烷、环庚烷、吡喃、硫吡喃、吡咯烷或哌啶环；R₃ 和 R₄ 独立地为氢或低级烷基，或者 R₃ + R₄ 与所连接的碳原子一起形成环戊烷、环己烷、环庚烷、吡喃、硫吡喃、吡咯烷或哌啶环、芳基是指未取代的苯基或被 1、2 或 3 个取代基取代的苯基，每个取代基都是独立的低级烷基、低级烷氧基、羟基、卤素、低级烷硫基、氰基、氨基或三氟甲基，以及它们的制备方法。这些化合物可用作抗精神病药、镇痛药、抗惊厥药和抗焦虑药。
• US4933453A
  申请人：——

  公开号：US4933453A

  公开（公告）日：1990-06-12
• US5037984A
  申请人：——

  公开号：US5037984A

  公开（公告）日：1991-08-06
• US5136037A
  申请人：——

  公开号：US5136037A

  公开（公告）日：1992-08-04