N-hydroxyethyl-2,5-dimethylpiperazine | 99769-12-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-hydroxyethyl-2,5-dimethylpiperazine
• 英文别名: 2-(2,5-Dimethylpiperazin-1-yl)ethanol
• CAS: 99769-12-7
• 化学式: C₈H₁₈N₂O
• 分子量: 158.244
• InChiKey: DEMJSCKEDLLJBK-UHFFFAOYSA-N

物化性质

• 沸点：
  259℃
• 密度：
  0.938
• 闪点：
  110℃

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-hydroxyethyl-2,5-dimethylpiperazine 、 2-bromoethyl triphenylmethyl sulfide 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以32 %的产率得到2-[2,5-Dimethyl-4-(2-tritylsulfanylethyl)piperazin-1-yl]ethanol
  参考文献：
  名称：

  [EN] ASYMMETRIC PIPERAZINE-BASED CATIONIC LIPIDS
  [FR] LIPIDES CATIONIQUES À BASE DE PIPÉRAZINE ASYMÉTRIQUE

  摘要：

  The present invention provides, in part, asymmetric piperazine-based lipid compounds of Formula (I'), and sub-formulas thereof or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

  公开号：

  WO2023178167A1

文献信息

• Interchangeable process scheme
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0197612A2

  公开（公告）日：1986-10-15

  Process for utilizing a reaction zone containing a catalyst to interchangeably conduct separate organic amine condensation reactions and a separation zone to interchangeably conduct separations of the reaction product streams of such reactions. A first organic condensation reaction using a first reactant or set of reactants is conducted in the reaction zone in the presence of a catalytically effective amount of the catalyst and at a temperature and pressure sufficient for the first organic condensation reaction to occur. Then, after termination of the first organic condensation reaction, a second organic condensation reaction using a second reactant or set of reactants is conducted in the reaction zone in the presence of a catalytically effective amount of the catalyst and at a temperature and pressure sufficient for the second organic condensation reaction to occur. The reaction product from each of the separate organic reactions is separated into at least one component, e.g., reaction product, using the same separation zone. The reaction zone contains at least two distillation columns, preferably five distillation columns.

  利用含有催化剂的反应区交替进行单独的有机胺缩合反应，以及利用分离区交替进行这些反应的反应产物流的分离的工艺。在反应区中，在催化剂有效量的存在下，在足以发生第一个有机缩合反应的温度和压力下，使用第一种反应物或一组反应物进行第一个有机缩合反应。然后，在第一有机缩合反应终止后，在催化剂的有效催化量存在下，在足以发生第二有机缩合反应的温度和压力下，在反应区中使用第二反应物或一组反应物进行第二有机缩合反应。来自每个独立有机反应的反应产物使用相同的分离区分离成至少一种组分，例如反应产物。反应区至少包含两个蒸馏塔，最好是五个蒸馏塔。
• Closed cell rigid polyurethane foam laminates
  申请人：ARCO Chemical Technology, L.P.

  公开号：EP0364156A2

  公开（公告）日：1990-04-18

  Substantially closed cell rigid polyurethane foam cores of laminates are disclosed which are scorch-free, have a density not greater than 50 kg/m³ and are made using water as the sole or main blowing agent and without the need to use a CFC. The foams are prepared from polyol compositions comprising the product of alkoxylating an initiator having a functionality of more than 2, at least one aromatic ring and at least one amino nitrogen atom. The initiator is preferably a Mannich condensate of a phenolic compound, formaldehyde and ammonia or an alkanolamine and the polyol is prefably used together with a second polyol having a functionality (or average functionality) of at least 1 but less than 3 and a molecular weight Mw (or average molecular weight) of 250 to 4000.

  本发明公开了基本闭孔硬质聚氨酯泡沫塑料芯材的层压板，这些泡沫塑料芯材无焦烧现象，密度不大于 50 kg/m³，并以水作为唯一或主要发泡剂，无需使用氟氯化碳。这些泡沫塑料由多元醇组合物制备而成，多元醇组合物包括将官能度大于 2 的引发剂、至少一个芳香环和至少一个氨基氮原子烷氧基化的产物。引发剂最好是酚类化合物、甲醛和氨或烷醇胺的曼尼希缩合物，多元醇最好与第二种多元醇一起使用，第二种多元醇的官能度（或平均官能度）至少为 1 但小于 3，分子量 Mw（或平均分子量）为 250 至 4000。
• Thermosettable compositions containing alkoxylated aromatic compounds
  申请人：ARCO Chemical Technology, L.P.

  公开号：EP0454446A1

  公开（公告）日：1991-10-30

  A rigid polyurethane-modified polyisocyanurate composition having improved physical properties obtained by curing a thermosettable composition containing an alkoxylated aromatic compound, organic polyisocyanate and a liquid modifying agent such as a cyclic alkylene carbonate using an isocyanate trimerization catalyst. The use of an alkoxylated aromatic compound permits a reduction in the proportion of organic polyisocyanate required to achieve satisfactory tensile strength and stiffness. The cured compositions are useful for the production of composites as well as molded articles containing reinforcing fillers

  一种硬质聚氨酯改性聚异氰酸酯组合物，通过使用异氰酸酯三聚催化剂固化含有烷氧基化芳香族化合物、有机多异氰酸酯和液体改性剂（如环状碳酸亚烷基酯）的热固化组合物，可获得更好的物理性能。使用烷氧基化芳香族化合物可以减少有机多异氰酸酯的比例，从而达到令人满意的拉伸强度和刚度。固化后的组合物可用于生产复合材料以及含有增强填料的模塑制品。
• Water blown rigid polyurethane foam with improved fire retardancy
  申请人：——

  公开号：US20020040122A1

  公开（公告）日：2002-04-04

  A rigid water blown polyurethane foam with improved and unexpected fire retardancy can be prepared from a formulation including a B component which is a mixture of a first polyol that is an ultra low viscosity Mannich polyol and a second polyol that is not. The foams of the present invention are particularly useful for spray foam, pour-in-place, and lamination applications and have properties similar to conventional foams.

  一种硬质水发泡聚氨酯泡沫可由一种配方制备而成，该配方包括 B 组分，B 组分是超低粘度曼尼希多元醇的第一种多元醇与非超低粘度曼尼希多元醇的第二种多元醇的混合物。本发明的泡沫塑料特别适用于喷射泡沫、现浇和层压应用，并具有与传统泡沫塑料类似的特性。
• Novel polyols for the production of rigid polyurethane foams
  申请人：MOBAY CORPORATION

  公开号：EP0125677B1

  公开（公告）日：1990-03-07