[2,2']Bipyridinyl-4,4'-dicarboxylic acid 4-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-amide} 4'-({2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-hydroxymethyl-ethyl}-amide) | 331465-55-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: [2,2']Bipyridinyl-4,4'-dicarboxylic acid 4-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-amide} 4'-({2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-hydroxymethyl-ethyl}-amide)
• 英文别名: 2-[4-[[1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[tert-butyl(dimethyl)silyl]oxypropan-2-yl]carbamoyl]pyridin-2-yl]-N-[1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-hydroxypropan-2-yl]pyridine-4-carboxamide
• CAS: 331465-55-5
• 化学式: C₆₆H₇₂N₄O₁₀Si
• 分子量: 1109.4
• InChiKey: XPKZVKSZPKDYAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.41
• 重原子数：
  81
• 可旋转键数：
  26
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  169
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  [2,2']Bipyridinyl-4,4'-dicarboxylic acid 4-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-amide} 4'-({2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-hydroxymethyl-ethyl}-amide) 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Succinic acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-({4'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-propyl ester pentafluorophenyl ester
  参考文献：
  名称：

  Solid-phase synthesis of oligonucleotides containing a Bipyridine ligand at the 3′-3′ inversion of polarity site

  摘要：

  The preparation of a solid support useful for the synthesis of oligonucleotides with a 3'-3' inversion of polarity, via a linker containing a chelating molecule, namely 2,2'-bipyridine, is described. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00673-9
• 作为产物：
  描述：

  2-amino-1-O-(4,4'-dimethoxytrityl)propane-1,3-diol 在 吡啶 、 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 [2,2']Bipyridinyl-4,4'-dicarboxylic acid 4-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-amide} 4'-({2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-hydroxymethyl-ethyl}-amide)
  参考文献：
  名称：

  Solid-phase synthesis of oligonucleotides containing a Bipyridine ligand at the 3′-3′ inversion of polarity site

  摘要：

  The preparation of a solid support useful for the synthesis of oligonucleotides with a 3'-3' inversion of polarity, via a linker containing a chelating molecule, namely 2,2'-bipyridine, is described. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00673-9

文献信息

• Solid-phase synthesis of oligonucleotides containing a Bipyridine ligand at the 3′-3′ inversion of polarity site
  作者：Aldo Galeone、Luciano Mayol、Giorgia Oliviero、Daniela Rigano、Michela Varra

  DOI：10.1016/s0960-894x(00)00673-9

  日期：2001.2

  The preparation of a solid support useful for the synthesis of oligonucleotides with a 3'-3' inversion of polarity, via a linker containing a chelating molecule, namely 2,2'-bipyridine, is described. (C) 2001 Elsevier Science Ltd. All rights reserved.