t-butyl 1-{3-[(naphth-1-ylsulfonyl)methyl]-4-nitrophenyl}-piperidin-4-ylcarbamate | 1086838-55-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: t-butyl 1-{3-[(naphth-1-ylsulfonyl)methyl]-4-nitrophenyl}-piperidin-4-ylcarbamate
• 英文别名: tert-butyl N-[1-[3-(naphthalen-1-ylsulfonylmethyl)-4-nitrophenyl]piperidin-4-yl]carbamate
• CAS: 1086838-55-2
• 化学式: C₂₇H₃₁N₃O₆S
• 分子量: 525.626
• InChiKey: RZXHZCRFTJEWQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  tert-butyl N-[1-[4-amino-3-(naphthalen-1-ylsulfonylmethyl)phenyl]piperidin-4-yl]carbamate 在 10% palladium on carbon 、 氢气 作用下， 生成 t-butyl 1-{3-[(naphth-1-ylsulfonyl)methyl]-4-nitrophenyl}-piperidin-4-ylcarbamate
  参考文献：
  名称：

  5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT₆ Receptor Antagonists

  摘要：

  Novel 5-cyclic amine-3-arylsulfonylindazoles were prepared, and several analogues within this class have been identified as high-affinity 5-HT6 receptor ligands with improved pharmacokinetic and pharmacological properties. One selected example, 18b, showed good brain penetrability and a generally favorable pharmacokinetic profile with procognitive efficacy in the rat novel object recognition assay. The synthesis and structure activity relationship of this potent class are discussed.

  DOI：

  10.1021/jm901674f

文献信息

• AMINOAZACYCLYL-3-SULFONYLINDAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS
  申请人：Haydar Simon Nicolas

  公开号：US20080293688A1

  公开（公告）日：2008-11-27

  The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.

  本发明提供了一种式I的化合物及其在治疗与5-HT6受体相关或受其影响的疾病中的应用。
• US7939520B2
  申请人：——

  公开号：US7939520B2

  公开（公告）日：2011-05-10
• [EN] 5- (AMINOAZACYCLYL) -3-SULFONYL-LH- INDAZOLES AS 5-HYDROXYTRYPTAMINE- 6 LIGANDS FOR THE TREATMENT OF CNS DISORDERS<br/>[FR] 5-(AMINOAZACYCLYL)-3-SULFONYL-1H-INDAZOLES EN TANT QUE LIGANDS DE D-HYDROXYTRYPTAMINE-6 POUR LE TRAITEMENT DE TROUBLES DU SYSTÈME NERVEUX CENTRAL (SNC)
  申请人：WYETH CORP

  公开号：WO2008144299A1

  公开（公告）日：2008-11-27

  [EN] The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of central nervous system disorders related to or affected by the 5-HT6 receptor.
  [FR] La présente invention propose un composé de formule I et son utilisation dans le traitement thérapeutique de troubles du système nerveux central concernés par le récepteur 5-HT6 ou sur lesquels le récepteur 5-HT6 a une incidence.
• 5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT₆ Receptor Antagonists
  作者：Simon N. Haydar、Heedong Yun、Patrick M. Andrae、James Mattes、Jean Zhang、Angela Kramer、Deborah L. Smith、Christine Huselton、Radka Graf、Suzan Aschmies、Lee E. Schechter、Thomas A. Comery、Albert J. Robichaud

  DOI：10.1021/jm901674f

  日期：2010.3.25

  Novel 5-cyclic amine-3-arylsulfonylindazoles were prepared, and several analogues within this class have been identified as high-affinity 5-HT6 receptor ligands with improved pharmacokinetic and pharmacological properties. One selected example, 18b, showed good brain penetrability and a generally favorable pharmacokinetic profile with procognitive efficacy in the rat novel object recognition assay. The synthesis and structure activity relationship of this potent class are discussed.