N-(6-羟基己基)哌啶 | 4711-14-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: N-(6-羟基己基)哌啶
• 英文名称: N-(6-hydroxyhexyl)piperidine
• 英文别名: 6-piperidino-1-hexanol；6-(1-piperidinyl)-1-hexanol；6-piperidino-hexan-1-ol；6-(1-piperidinyl)hexanol；6-piperidino-hexanol；6-piperidin-1-ylhexan-1-ol
• CAS: 4711-14-2
• 化学式: C₁₁H₂₃NO
• 分子量: 185.31
• InChiKey: FWZJLZKQMRVPLR-UHFFFAOYSA-N

物化性质

• 沸点：
  96 °C(Press: 1 Torr)
• 密度：
  0.932±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(6-羟基己基)哌啶 生成 3,5-dinitro-benzoic acid-(6-piperidino-hexyl ester)
  参考文献：
  名称：

  The Selective Hydrogenation of Substituted Amides

  摘要：

  DOI：

  10.1021/ja01269a048
• 作为产物：
  描述：

  6-氯-6-氧代己酸乙酯 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 N-(6-羟基己基)哌啶
  参考文献：
  名称：

  Avison, Journal of Applied Chemistry, 1951, vol. 1, p. 469,470

  摘要：

  DOI：

文献信息

• Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease
  作者：Li Luo、Qing Song、Yan Li、Zhongcheng Cao、Xiaoming Qiang、Zhenghuai Tan、Yong Deng

  DOI：10.1016/j.bmc.2020.115400

  日期：2020.4

  of phthalide alkyl tertiary amine derivatives were designed, synthesized and evaluated as potential multi-target agents against Alzheimer’s disease (AD). The results indicated that almost all the compounds displayed significant AChE inhibitory and selective activities. Besides, most of the derivatives exhibited increased self-induced Aβ1-42 aggregation inhibitory activity compared to the lead compound

  设计，合成和评估了一系列邻苯二甲酰基烷基叔胺衍生物，作为对抗阿尔茨海默氏病（AD）的潜在多靶标药物。结果表明，几乎所有化合物均显示出显着的AChE抑制和选择性活性。此外，大多数的衍生物显示出增加的自感甲β 1-42相比，铅化合物聚集抑制活性DL -NBP，有些化合物也发挥良好的抗氧化活性。具体而言，化合物I-8对AChE的抑制力最高（IC 50 = 2.66 nM），明显优于多奈哌齐（IC 50 = 26.4 nM）。此外，分子对接研究表明I-8可以与AChE的催化活性位点和外围阴离子位点结合。此外，化合物I-8在体外显示出优异的BBB渗透性。重要的是，逐步降低的被动回避测试表明，I-8可显着逆转东amine碱诱导的小鼠记忆缺陷。总的来说，这些结果表明I-8可能是用于进一步抗AD药物开发的有效且选择性的AChE抑制剂。
• Fused bicyclic amide compounds and medicinal use thereof
  申请人：——

  公开号：US20030203909A1

  公开（公告）日：2003-10-30

  The present invention provides a compound represented by the formula (I) 1 wherein ring A is benzene, cyclohexane, pyridine, piperidine or a derivative thereof, imidazole or a derivative thereof and the like, ring B is benzene, cyclohexane, pyrrole or a derivative thereof, furan, thiophene and the like, R 1 , R 2 and R 3 are each hydrogen, alkyl, halogen, hydroxyl group, alkoxy and the like, W is hydrogen, alkyl or hydroxycarbonylalkyl, X is halogen, cyano, nitro and the like, X′ is hydrogen, halogen and the like, and Y is alkyl, hydroxyalkyl, hydroxycarbonylalkyl, aminoalkyl and the like, a salt thereof, and a pharmaceutical agent containing the compound. The compound of the present invention shows a superior inhibitory effect on the proliferation of activated lymphocyte and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

  本发明提供了一种由以下化学式（I）1所代表的化合物，其中环A为苯、环己烷、吡啶、哌啶或其衍生物、咪唑或其衍生物等，环B为苯、环己烷、吡咯或其衍生物、呋喃、噻吩等，R1、R2和R3分别为氢、烷基、卤素、羟基、烷氧基等，W为氢、烷基或羟基羰基烷基，X为卤素、氰基、硝基等，X′为氢、卤素等，Y为烷基、羟基烷基、羟基羰基烷基、氨基烷基等，其盐和含有该化合物的药物。本发明的化合物对活化淋巴细胞的增殖具有优越的抑制作用，并可用作各种自身免疫性疾病的预防或治疗剂。
• [EN] POLYOLS AND THEIR USE IN HYDROCARBON LUBRICATING AND DRILLING FLUIDS<br/>[FR] POLYOLS ET LEUR UTILISATION DANS DES FLUIDES HYDROCARBONÉS DE LUBRIFICATION ET DE FORAGE
  申请人：LORD CORP

  公开号：WO2012106597A1

  公开（公告）日：2012-08-09

  Polyhydroxyl functional compounds that contain an all hydrocarbon backbone, wherein all of the hydroxyl groups are bonded to a primary carbon atom, are prepared through the reaction of an alpha, omega-terminal diol having a total of from about 6 to about 42 carbon atoms terminated with a mono-ol having a total of from about 4 to about 42 carbon atoms. The polyols can be used as additives in hydrocarbon oils, drilling fluids, industrial and automotive lubricating fluids, dispersants, engine lubricants, greases, coatings, adhesives, and also in magnetorheological fluids to improve various properties such as dispersion, wear protection, reduction of friction, high temperature stability, and improved aging.

  通过将总共约6至42个碳原子的α，ω-末端二醇与总共约4至42个碳原子的单醇反应制备含有全碳氢骨架的多羟基功能化合物，其中所有羟基均与一级碳原子键合。这些聚醇可用作烃类油、钻井液、工业和汽车润滑油、分散剂、发动机润滑油、润滑脂、涂料、粘合剂以及磁流变流体的添加剂，以改善各种性能，如分散性、耐磨保护、减少摩擦、高温稳定性和改善老化。
• PROCESS FOR PREPARING (METH)ACRYLIC ACID
  申请人：Vogel Bernd

  公开号：US20100029979A1

  公开（公告）日：2010-02-04

  The present invention relates to a process for preparing (meth)acrylic acid, characterized in that a cyclic ester is converted to (meth)acrylic acid in the presence of a catalyst. The (meth)acrylic acid prepared can in particular be converted to (meth)acrylates.

  本发明涉及一种制备（甲基）丙烯酸的方法，其特征在于在催化剂的存在下将环状酯转化为（甲基）丙烯酸。制备的（甲基）丙烯酸可以特别地转化为（甲基）丙烯酸酯。
• PROCESS FOR PREPARING TETRAMETHYL GLYCOLIDE
  申请人：Vogel Bernd

  公开号：US20100010276A1

  公开（公告）日：2010-01-14

  The present invention relates to a process for preparing tetramethylglycolide by heating a composition which comprises at least 50% by weight of 2-hydroxy-isobutyric acid and/or tetramethylglycolide to a temperature of at least 100° C.

  本发明涉及一种制备四甲基乙二酰乙酯的方法，包括将含有至少50%重量的2-羟基异丁酸和/或四甲基乙二酰乙酯的组合物加热至至少100℃的温度。