1-tert-Butyl-4-(2-methoxy-phenyl)-piperazine | 6322-41-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-tert-Butyl-4-(2-methoxy-phenyl)-piperazine
• 英文别名: 1-Tert-butyl-4-(2-methoxyphenyl)piperazine
• CAS: 6322-41-4
• 化学式: C₁₅H₂₄N₂O
• 分子量: 248.368
• InChiKey: IQIIUWCFJHTWEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL INDENO[1,2-c]QUINOLIN-11-ONE DERIVATIVES, PREPARATION METHOD AND APPLICATION THEREOF
  申请人：National Defense Medical Center

  公开号：US20150197492A1

  公开（公告）日：2015-07-16

  The present invention provides a novel series of indeno[1,2-c]quinolin-11-one derivatives and further provides their preparation methods as well as applications. Said applications includes utilizing such derivatives as pharmaceutical compositions for treating cancers; moreover, said applications includes the capability possessed by such derivatives to effectively inhibit cancer cell growth as well as the activity of Type I topoisomerases and can be further applied for cancer treatment.

  本发明提供了一系列新颖的indeno[1,2-c]quinolin-11-one衍生物，并进一步提供其制备方法以及应用。所述应用包括将这些衍生物用作治疗癌症的药物组合物；此外，所述应用包括这些衍生物具有有效抑制癌细胞生长以及抑制Ⅰ型拓扑异构酶活性的能力，并可进一步应用于癌症治疗。
• Substituted Piperidines that Increase P53 Activity and the Uses Thereof
  申请人：Ma Yao

  公开号：US20080004287A1

  公开（公告）日：2008-01-03

  In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.

  在其多种实施形式中，本发明披露了作为HDM2蛋白抑制剂的新型化合物，制备这种化合物的方法，包括一种或多种这种化合物的药物组合物，以及利用这种化合物或药物组合物进行与HDM2蛋白或P53相关的一种或多种疾病的治疗、预防、抑制方法。
• 2,4-Disubstituted-5-Aminocarbonyl-1,3-Thiazole Derivatives For Therapeutic Agent Of Antiinflammatory Disease, Method Thereof For Preparation, Therapeutic Agent For Antiinflammatory Disease Induced By SPC Activity Containing The Same
  申请人：Gong Young-Dae

  公开号：US20100145043A1

  公开（公告）日：2010-06-10

  Disclosed herein are 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives, a preparation method thereof, and a therapeutic agent for treating inflammatory diseases induced by SPC, which contains the derivative as an active ingredient. The anti-inflammatory effect of the 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives was analyzed through a test employing human dermal cells and an animal test using mice and, as a result, it was found that the derivatives showed excellent inhibitory activity on SPC receptor compared to thiazole derivatives known in the prior art. Thus, the 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives or pharmaceutically acceptable salts thereof are useful as active ingredients in therapeutic agents for treating inflammatory diseases, such as inflammation, pruritus and skin infection, which appear in atopic dermatitis and other diseases induced by SPC activity. wherein R 1 , R 2 , R 3 and R 4 are as defined in the specification.

  本文公开了2,4-二取代-5-氨基甲酰基-1,3-噻唑衍生物及其制备方法，以及作为活性成分的治疗SPC引起的炎症性疾病的治疗剂。通过使用人皮肤细胞测试和小鼠动物测试分析了2,4-二取代-5-氨基甲酰基-1,3-噻唑衍生物的抗炎作用，结果发现与先前已知的噻唑衍生物相比，该衍生物对SPC受体表现出优异的抑制活性。因此，2,4-二取代-5-氨基甲酰基-1,3-噻唑衍生物或其药学上可接受的盐可用作治疗炎症性疾病的活性成分，例如在特应性皮炎和其他由SPC活性引起的疾病中出现的炎症，瘙痒和皮肤感染。其中，R1，R2，R3和R4如规范中所定义。
• US7504391B2
  申请人：——

  公开号：US7504391B2

  公开（公告）日：2009-03-17
• US7884107B2
  申请人：——

  公开号：US7884107B2

  公开（公告）日：2011-02-08