6-[4-(1,3-Benzodioxol-5-ylmethyl)piperazino]-3-phenyl[1,2,4]triazolo[4,3-B]pyridazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-[4-(1,3-Benzodioxol-5-ylmethyl)piperazino]-3-phenyl[1,2,4]triazolo[4,3-B]pyridazine
• 英文别名: 6-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine
• 化学式: C₂₃H₂₂N₆O₂
• mdl: MFCD05859222
• 分子量: 414.5
• InChiKey: RKQOKTDPFSZVCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  68
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Methods for treating cryptosporidiosis using triazolopyridazines
  申请人：University of Vermont and State Agricultural College

  公开号：US10363254B2

  公开（公告）日：2019-07-30

  Methods for treating or prophylaxis of a Cryptosporidium infection using compositions comprising a structure disclosed herein. Also provided are pharmaceutical compositions and kits for alleviating the symptoms of, for treating, or for preventing the occurrence of Cryptosporidium infection. The kits comprise one or more compounds having a structure disclosed herein, such as in an oral composition, and instructions for use, storage, and the like.

  使用包含本文公开的结构的组合物治疗或预防隐孢子虫感染的方法。还提供了用于缓解隐孢子虫感染症状、治疗或预防隐孢子虫感染发生的药物组合物和试剂盒。这些试剂盒包括一种或多种具有本文所公开结构的化合物，如口服组合物，以及使用、储存等说明。
• METHODS FOR TREATING CRYPTOSPORIDIOSIS USING TRIAZOLOPYRIDAZINES
  申请人：University of Vermont and State Agricultural College

  公开号：US20180064711A1

  公开（公告）日：2018-03-08

  Methods for treating or prophylaxis of a Cryptosporidium infection using compositions comprising a structure disclosed herein. Also provided are pharmaceutical compositions and kits for alleviating the symptoms of, for treating, or for preventing the occurrence of Cryptosporidium infection. The kits comprise one or more compounds having a structure disclosed herein, such as in an oral composition, and instructions for use, storage, and the like.
• [EN] METHODS FOR TREATING CRYPTOSPORIDIOSIS USING TRIAZOLOPYRIDAZINES<br/>[FR] MÉTHODES POUR LE TRAITEMENT DE LA CRYPTOSPORIDIOSE À L'AIDE DE TRIAZOLOPYRIDAZINES
  申请人：UNIV OF VERMONT AND STATE AGRICULTURAL COLLEGE

  公开号：WO2016161125A1

  公开（公告）日：2016-10-06

  Methods for treating or prophylaxis of a Cryptosporidium infection using compositions comprising a structure disclosed herein. Also provided are pharmaceutical compositions and kits for alleviating the symptoms of, for treating, or for preventing the occurrence of Cryptosporidium infection. The kits comprise one or more compounds having a structure disclosed herein, such as in an oral composition, and instructions for use, storage, and the like.