3,4-Dihydro-3-phenyl-2H-1-benzothiopyran | 120229-44-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫铬烷
• 英文名称: 3,4-Dihydro-3-phenyl-2H-1-benzothiopyran
• 英文别名: 3-Phenylthiochroman；3-phenyl-3,4-dihydro-2H-thiochromene
• CAS: 120229-44-9
• 化学式: C₁₅H₁₄S
• 分子量: 226.342
• InChiKey: UDRWYFKYTSHKCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯乙烯 、 2H-benzo[b]thiete 以 甲苯 为溶剂， 反应 3.5h， 以13%的产率得到6H,12H-Dibenzo<1,5>dithiocin
  参考文献：
  名称：

  Meier, Herbert; Schmidt, Michael; Eckes, Heinz-Ludwig, Chemische Berichte, 1989, vol. 122, p. 1545 - 1550

  摘要：

  DOI：

文献信息

• Selective estrogen receptor modulators in combination with estrogens
  申请人：Endorecherche, Inc.

  公开号：US20020198179A1

  公开（公告）日：2002-12-26

  Novel methods for reduction or elimination the incidence of hot flashes and menopausal symptoms, while decreasing the risk of acquiring breast or endometrial cancer and furthermore treating and/or inhibiting the development of osteoporosis, hypercholesterolemia, hyperlipidemia, atherosclerosis, hypertension, insulin resistance, diabetes, loss of muscle mass, obesity, irregular menstruation, Alzheimer's disease, or vaginal dryness in susceptible warm-blooded animals including humans involving administration of selective estrogen receptor modulator, particularly compounds having the general structure: 1 and an amount of an estrogen or mixed estrogenic/androgenic compound. Further administration of bisphosphonates, or sex steroid precursor is specifically disclosed for the medical treatment and/or inhibition of development of some of these above-mentioned diseases. Pharmaceutical compositions for delivery of active ingredient(s) and kit(s) useful to the invention are also disclosed.

  减少或消除潮热和更年期症状的新方法，同时降低罹患乳腺癌或子宫内膜癌的风险，并进一步治疗和/或抑制骨质疏松症、高胆固醇血症、高脂血症、动脉粥样硬化、高血压、胰岛素抵抗、糖尿病、肌肉质量下降、肥胖症、月经不调、老年痴呆症或阴道干涩等疾病的发展、在包括人类在内的易感温血动物中使用选择性雌激素受体调节剂，特别是具有一般结构的化合物，以治疗和/或抑制骨质疏松症、高胆固醇血症、高脂血症、动脉粥样硬化、高血压、胰岛素抵抗、糖尿病、肌肉质量下降、肥胖、月经不调、老年痴呆症或阴道干涩： 1 和一定量的雌激素或雌激素/雄激素混合化合物。还特别公开了双磷酸盐或性类固醇前体的进一步施用，用于治疗和/或抑制上述某些疾病的发展。此外，还公开了用于输送活性成分的药物组合物和对本发明有用的试剂盒。
• The use of 2-phenyltetralin derivatives, or heterocyclic analogues, in medicine and pharmaceutical compositions containing them
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0025598B1

  公开（公告）日：1984-08-01
• SELECTIVE ESTROGEN RECEPTOR MODULATORS IN COMBINATION WITH ESTROGENS
  申请人：Endorecherche, Inc.

  公开号：EP1251855A1

  公开（公告）日：2002-10-30
• US4801593A
  申请人：——

  公开号：US4801593A

  公开（公告）日：1989-01-31
• [EN] SELECTIVE ESTROGEN RECEPTOR MODULATORS IN COMBINATION WITH ESTROGENS<br/>[FR] MODULATEURS SELECTIFS DU RECEPTEUR D'OESTROGENE, EN COMBINAISON AVEC DES OESTROGENES
  申请人：ENDORECH INC

  公开号：WO2001054699A1

  公开（公告）日：2001-08-02

  Novel methods for reduction or elimination of the incidence of hot flashes and menopausal symptoms, while decreasing the risk of acquiring breast or endometrial cancer and furthermore treating and/or inhibiting the development of osteoporosis, hypercholesterolemia, hyperlipidemia, atherosclerosis, hypertension, insulin resistance, diabetes, loss of muscle mass, obesity, irregular menstruation, Alzheimer's disease, or vaginal dryness in susceptible warm-blooded animals including humans involving administration of selective estrogen receptor modulator, particularly compounds having the general structure (I) and an amount of an estrogen or mixed estrogenic/androgenic compound. Further administration of bisphosphonates, or sex steroid precursor is specifically disclosed for the medical treatment and/or inhibition of development of some of these above-mentioned diseases. Pharmaceutical compositions for delivery of active ingredient(s) and kit(s) useful to the invention are also disclosed.