N-Boc-8-羟基-5-氮杂螺[3.5]壬烷 | 929971-93-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: N-Boc-8-羟基-5-氮杂螺[3.5]壬烷
• 英文名称: Tert-butyl 8-hydroxy-5-azaspiro[3.5]nonane-5-carboxylate
• CAS: 929971-93-7
• 化学式: C₁₃H₂₃NO₃
• mdl: MFCD09040692
• 分子量: 241.33
• InChiKey: HEGAYMHXIDYCSW-UHFFFAOYSA-N

物化性质

• 沸点：
  350.7±35.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.923
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS
  申请人：CHIESI FARMACEUTICI S.p.A.

  公开号：US20220227749A1

  公开（公告）日：2022-07-21

  The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X 3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
• [EN] AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS<br/>[FR] DÉRIVÉS D'AMINO QUINAZOLINE SERVANT D'INHIBITEURS DE P2X3
  申请人：CHIESI FARM SPA

  公开号：WO2020239952A1

  公开（公告）日：2020-12-03

  The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).