3-[4-(4-hydroxyphenyl)piperazin-1-yl]-1-phenyl-1H-pyrrole-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-[4-(4-hydroxyphenyl)piperazin-1-yl]-1-phenyl-1H-pyrrole-2,5-dione
• 英文别名: 3-[4-(4-hydroxyphenyl)piperazin-1-yl]-1-phenylpyrrole-2,5-dione
• 化学式: C₂₀H₁₉N₃O₃
• 分子量: 349.4
• InChiKey: SRDISNLLTYRBNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Compounds for the Treatment Of Acute and Chronic Kidney Disease
  申请人：Southern Research Institute

  公开号：US20220153695A1

  公开（公告）日：2022-05-19

  The present disclosure is concerned with biaryl aminomaleimide compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• [EN] COMPOUNDS FOR THE TREATMENT OF ACUTE AND CHRONIC KIDNEY DISEASE<br/>[FR] COMPOSÉS POUR LE TRAITEMENT D'UNE NÉPHROPATHIE AIGUË ET CHRONIQUE
  申请人：[en]SOUTHERN RESEARCH INSTITUTE

  公开号：WO2022109066A1

  公开（公告）日：2022-05-27

  The present disclosure is concerned with biaryl aminomaleimide compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases ( e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.