N-(2-methoxyphenyl)-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-(2-methoxyphenyl)-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide
• 英文别名: N-(2-methoxyphenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide
• 化学式: C₁₈H₂₂N₄O₂
• mdl: MFCD05147200
• 分子量: 326.4
• InChiKey: DGDPIUHYQDINOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  57.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：EP1417177A2

  公开（公告）日：2004-05-12
• EP1417177A4
  申请人：——

  公开号：EP1417177A4

  公开（公告）日：2005-10-19
• [EN] ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS<br/>[FR] ACYLSEMICARBAZIDES INHIBITEURS DE KINASE DEPENDANT DE LA CYCLINE UTILES EN TANT QU'AGENTS ANTICANCEREUX ET ANTIPROLIFERATIFS
  申请人：BRISTOL MYERS SQUIBB PHARMA CO

  公开号：WO2003007883A2

  公开（公告）日：2003-01-30

  The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I) that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.