1,1’-(piperizine-1,4-diyl)bis(hexan-1-one) | 18903-09-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,1’-(piperizine-1,4-diyl)bis(hexan-1-one)
• 英文别名: 1,4-dihexanoyl-piperazine；1,4-Dihexanoyl-piperazin；1,4-bis(1-oxohexyl)-piperazine；Piperazine, 1,4-dihexanoyl-；1-(4-hexanoylpiperazin-1-yl)hexan-1-one
• CAS: 18903-09-8
• 化学式: C₁₆H₃₀N₂O₂
• 分子量: 282.426
• InChiKey: FDZTWQOEIFKHDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  piperazine dihydrochloride hydrate 、 己酰氯 在 乙醚 、 碳酸氢钠 作用下， 生成 1,1’-(piperizine-1,4-diyl)bis(hexan-1-one)
  参考文献：
  名称：

  Groszkowski et al., Annales Pharmaceutiques Francaises, 1958, vol. 16, p. 517,522, 524

  摘要：

  DOI：

文献信息

• Formation of Tertiary Amides and Dihydrogen by Dehydrogenative Coupling of Primary Alcohols with Secondary Amines Catalyzed by Ruthenium Bipyridine-Based Pincer Complexes
  作者：Dipankar Srimani、Ekambaram Balaraman、Peng Hu、Yehoshoa Ben-David、David Milstein

  DOI：10.1002/adsc.201300620

  日期：2013.9.16

  Dehydrogenative coupling of primary alcohols with secondary amines to form tertiary amides and dihydrogen (H2) is efficiently catalyzed by bipyridyl‐based ruthenium pincer complexes (0.2–1 mol%) under neutral conditions (in case of the dearomatized complexes), or with added catalytic amount of base. The reaction is sensitive to steric hindrance; in the case of amidation of bulky secondary amines a

  在中性条件下（对于脱芳烃化的配合物），基于联吡啶的钌钳配合物（0.2-1 mol％）有效地催化了伯醇与仲胺的脱氢偶联反应，形成叔酰胺和二氢（H 2）。催化量的碱。该反应对位阻敏感。在笨重的仲胺酰胺化的情况下，空间位阻较少的配合物更有效。还证明了在仲胺存在下对伯胺的选择性酰化。
• 1-Oxohydrocarbyl-substituted azacyclohexanes compositions used as acid catalyst
  申请人：WHITBY RESEARCH, Inc.

  公开号：EP0582065A1

  公开（公告）日：1994-02-09

  This invention provides a process for the conversion of a reactant into a reaction product in the presence of an acid catalyst which comprises contacting said reactant with an acid catalyst comprising a compound represented by the general formula wherein X may represent sulfur, oxygen or nitrogen; a and b may be 0 or 1, c may be 0,1 or 2, except that when X is oxygen, a, b and c are O, when X is nitrogen c is 0 and only one of a or b is 1, and when X is sulfur a and b are 0; A is a branched or a straight chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having from 1 to 4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkanoyl; and R is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, wherein R'' is H or halogen, and salts thereof, and Z is selected from the group consisting of anions of strong acids.

  本发明提供了一种在酸催化剂存在下将反应物转化为反应产物的工艺，该工艺包括将所述反应物与酸催化剂接触，酸催化剂由通式所代表的化合物组成。 其中 X 可以代表硫、氧或氮；a 和 b 可以是 0 或 1，c 可以是 0、1 或 2，但当 X 是氧时，a、b 和 c 是 O，当 X 是氮时，c 是 0，a 或 b 中只有一个是 1，当 X 是硫时，a 和 b 是 0；A 是支链或直链二价脂族基，具有 0 至 2 个双键；R'选自由 H、具有 1 至 4 个碳原子的低级烷基、苯基、低级烷基或卤素取代的苯基、乙酰氨基、卤素、哌啶基、低级烷基或卤素取代的哌啶基、碳烷氧基、羧酰胺和烷酰基组成的组；以及 R 为氢或具有 1 至 4 个碳原子的低级烷基、 其中 R''是氢或卤素，以及它们的盐，Z 选自强酸阴离子组成的组。
• COMPOSITIONS COMPRISING 1-ACYL-SUBSTITUTED MORPHOLINES, THIOMORPHOLINES AND PIPERAZINES AND THEIR USES
  申请人：WHITBY RESEARCH, Inc.

  公开号：EP0280703B1

  公开（公告）日：1993-12-29
• Decolorizable ink composition and ink jet printer using the ink composition
  申请人：Ricoh Company, Ltd.

  公开号：EP1149877B1

  公开（公告）日：2003-06-11
• US6527384B2
  申请人：——

  公开号：US6527384B2

  公开（公告）日：2003-03-04