N-[4-[[2-羟基-5-(叔-戊基)苯基]偶氮]苯基]苯酰胺 | 71889-77-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 中文名称: N-[4-[[2-羟基-5-(叔-戊基)苯基]偶氮]苯基]苯酰胺
• 中文别名: 1-苯并呋喃-5-甲脒
• 英文名称: 1-Benzofuran-5-carboximidamide
• CAS: 71889-77-5
• 化学式: C₉H₈N₂O
• 分子量: 160.17
• InChiKey: UVNHEZDLZLMVBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Use and administration of bacterial efflux pump inhibitors
  申请人：Bostion Keith

  公开号：US20060276473A1

  公开（公告）日：2006-12-07

  This invention provides for efflux pump inhibitors to be co-administered with antimicrobial agents for the treatment of infections caused by drug resistant pathogens, novel efflux pump inhibitors, combined dosage forms of efflux pump inhibitors with an antimicrobial, and novel medical methods.

  本发明提供了外输泵抑制剂与抗微生物药物联合使用，用于治疗由耐药病原体引起的感染，新型外输泵抑制剂，外输泵抑制剂与抗微生物剂的联合剂型以及新型医疗方法。
• Amidine derivatives for treating amyloidosis
  申请人：Chalifour J. Robert

  公开号：US20070021483A1

  公开（公告）日：2007-01-25

  The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited:

  本发明涉及在治疗与淀粉样相关疾病中使用氨基脲类化合物。特别地，本发明涉及一种治疗或预防受试者淀粉样相关疾病的方法，包括向受试者施用治疗剂量的氨基脲类化合物。根据本发明使用的化合物包括以下化学式的化合物，当施用时，可减少或抑制淀粉样纤维形成、神经退行性或细胞毒性：
• BACTERIAL EFFLUX PUMP INHIBITORS FOR THE TREATMENT OF OPHTHALMIC AND OTIC INFECTIONS
  申请人：Bostian Keith

  公开号：US20080132457A1

  公开（公告）日：2008-06-05

  Efflux pump inhibitors are co-administered with antimicrobial agents for the treatment of ophthalmic or otic infections. The agents may be co-administered directly to the site of infection (e.g., the eye or ear).

  流出泵抑制剂与抗微生物药物一起联合使用，用于治疗眼科或耳科感染。这些药物可以直接共同应用于感染部位（例如眼睛或耳朵）。
• NOVEL HALO-ALKOXYCARBONYL PRODRUGS
  申请人：GENENTECH, INC.

  公开号：US20010020019A1

  公开（公告）日：2001-09-06

  Halo-alkoxycarbonyl derivatives are provided as prodrug moieties for pharmaceutical agents containing a basic or polar nitrogen containing functionality. The prodrugs are provided as pharmaceutical compositions as well as in methods of treatment.

  卤代烷氧基羰基衍生物可作为含有碱性或极性含氮官能团的药剂的原药分子。这些原药既可作为药物组合物，也可用于治疗方法。
• Novel halo-alkoxycarbonyl prodrugs
  申请人：Genentech, Inc.

  公开号：US20040220401A1

  公开（公告）日：2004-11-04

  Halo-alkoxycarbonyl derivatives are provided as prodrug moieties for pharmaceutical agents containing a basic or polar nitrogen containing functionality. The prodrugs are provided as pharmaceutical compositions as well as in methods of treatment.

  卤代烷氧基羰基衍生物可作为含有碱性或极性含氮官能团的药剂的原药分子。这些原药既可作为药物组合物，也可用于治疗方法。