4-(4-Chloro-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)morpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4-(4-Chloro-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)morpholine
• 化学式: C₁₁H₁₆ClN₅O
• mdl: MFCD00737815
• 分子量: 269.734
• InChiKey: VPSFVUVVIZXTKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.727
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 2,4-二氯-6-吗啉基-1,3,5-三嗪 以 异丙醇 为溶剂， 生成 4-(4-Chloro-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)morpholine
  参考文献：
  名称：

  Kinetic studies on the Reaction of Cyanuric Chloride with Amines

  摘要：

  The individual steps in the reactions of cyanuric chloride with n-butyl amine in N-methyl pyrrolidone (NMP) and with morpholine in isopropanol (i-PrOH) were followed kinetically. The ratio of the exchange rates of the first, the second and the third chlorine atom was unexpectedly high in both cases. The reactions of n-butylamino dichlorotriazine with several amines were studied kinetically both in NMP and in i-PrOH. Linear free-energy relationships exist both between our values in NMP and in isopropanol and between our values and reaction rates of p-nitro fluorobenzene with the corresponding amines (in DMSO) determined by Suhr.

  DOI：

  10.1002/prac.19953370128

文献信息

• Kinetic studies on the Reaction of Cyanuric Chloride with Amines
  作者：Gerhard Just、Ina Pokorny、Wilhelm Pritzkow

  DOI：10.1002/prac.19953370128

  日期：——

  The individual steps in the reactions of cyanuric chloride with n-butyl amine in N-methyl pyrrolidone (NMP) and with morpholine in isopropanol (i-PrOH) were followed kinetically. The ratio of the exchange rates of the first, the second and the third chlorine atom was unexpectedly high in both cases. The reactions of n-butylamino dichlorotriazine with several amines were studied kinetically both in NMP and in i-PrOH. Linear free-energy relationships exist both between our values in NMP and in isopropanol and between our values and reaction rates of p-nitro fluorobenzene with the corresponding amines (in DMSO) determined by Suhr.