3-chloro-6-[(2R)-2-methylpiperazin-1-yl]pyridazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-chloro-6-[(2R)-2-methylpiperazin-1-yl]pyridazine
• 化学式: C₉H₁₃ClN₄
• 分子量: 212.68
• InChiKey: WQFIYKMYHMQVFA-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  41
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SMALL MOLECULE MODULATORS OF PANK
  申请人：St. Jude Children's Research Hospital

  公开号：US20220185796A1

  公开（公告）日：2022-06-16

  The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• [EN] SMALL MOLECULE MODULATORS OF PANK<br/>[FR] MODULATEURS À PETITES MOLÉCULES DE PANK
  申请人：ST JUDE CHILDRENS RES HOSPITAL

  公开号：WO2020198526A2

  公开（公告）日：2020-10-01

  The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.