(E)-But-2-enedioic acid bis-[4-(4-carboxy-3-methoxy-2,5,6-trimethyl-phenoxycarbonyl)-3-methoxy-2,5,6-trimethyl-phenyl] ester | 185677-91-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: (E)-But-2-enedioic acid bis-[4-(4-carboxy-3-methoxy-2,5,6-trimethyl-phenoxycarbonyl)-3-methoxy-2,5,6-trimethyl-phenyl] ester
• 英文别名: 4-[4-[(E)-4-[4-(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]-4-oxobut-2-enoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
• CAS: 185677-91-2
• 化学式: C₄₈H₅₂O₁₆
• 分子量: 884.931
• InChiKey: ZPZOFEXFOZMNDW-ISLYRVAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  64
• 可旋转键数：
  18
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  217
• 氢给体数：
  2
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  (E)-But-2-enedioic acid bis-[4-(4-carboxy-3-methoxy-2,5,6-trimethyl-phenoxycarbonyl)-3-methoxy-2,5,6-trimethyl-phenyl] ester 在 palladium on activated charcoal 氢气 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 以92%的产率得到Succinic acid bis-[4-(4-carboxy-3-methoxy-2,5,6-trimethyl-phenoxycarbonyl)-3-methoxy-2,5,6-trimethyl-phenyl] ester
  参考文献：
  名称：

  Synthesis and Phospholipase A₂ Inhibitory Activity of Thielocin B3 Derivatives

  摘要：

  We prepared several types of derivatives of thielocin B3, a very potent naturally occurring inhibitor for human nonpancreatic secretory PLA(2) (sPLA(2)-II), and conducted a structure-activity relationship study to identify potent sPLA(2)-II inhibitors with the aim of developing antiinflammatory drugs. The total number of aromatic rings is critical for sPLA(2)-II inhibition, and the best result was obtained in the case of six rings. The structure of the central part of the inhibitors was not specific, and potent inhibitors were found among the sulfide, sulfone, ether, methylene, and amino derivatives. Although a diester of the terminal carboxylic acid lost its inhibitory activity, having both of the carboxylic acids was not necessary for expression of activity, as illustrated by a glycine derivative with the benzyl ester group 36. Among the newly synthesized derivatives, 18, 20, 29, and 36 showed very potent human sPLA(2)-II inhibitory activity comparable to that of natural thielocin B3. Their IC50 values are in the range 0.069-0.14 mu M, and they are a class of compounds showing the most potent sPLA(2)-II inhibition to date.

  DOI：

  10.1021/jm960437a
• 作为产物：
  描述：

  benzhydryl 4-(2-methoxy-3,5,6-trimethyl-4-hydroxybenzoyloxy)-2-methoxy-3,5,6-trimethylbenzoate 在 正丁基锂 、 苯甲醚 、 三氟乙酸 作用下， 反应 0.5h， 生成 (E)-But-2-enedioic acid bis-[4-(4-carboxy-3-methoxy-2,5,6-trimethyl-phenoxycarbonyl)-3-methoxy-2,5,6-trimethyl-phenyl] ester
  参考文献：
  名称：

  Synthesis and Phospholipase A₂ Inhibitory Activity of Thielocin B3 Derivatives

  摘要：

  We prepared several types of derivatives of thielocin B3, a very potent naturally occurring inhibitor for human nonpancreatic secretory PLA(2) (sPLA(2)-II), and conducted a structure-activity relationship study to identify potent sPLA(2)-II inhibitors with the aim of developing antiinflammatory drugs. The total number of aromatic rings is critical for sPLA(2)-II inhibition, and the best result was obtained in the case of six rings. The structure of the central part of the inhibitors was not specific, and potent inhibitors were found among the sulfide, sulfone, ether, methylene, and amino derivatives. Although a diester of the terminal carboxylic acid lost its inhibitory activity, having both of the carboxylic acids was not necessary for expression of activity, as illustrated by a glycine derivative with the benzyl ester group 36. Among the newly synthesized derivatives, 18, 20, 29, and 36 showed very potent human sPLA(2)-II inhibitory activity comparable to that of natural thielocin B3. Their IC50 values are in the range 0.069-0.14 mu M, and they are a class of compounds showing the most potent sPLA(2)-II inhibition to date.

  DOI：

  10.1021/jm960437a

文献信息

• PHOSPHOLIPASE A2 INHIBITOR
  申请人：SHIONOGI & CO., LTD.

  公开号：EP0547231B1

  公开（公告）日：1996-08-28
• US5597943A
  申请人：——

  公开号：US5597943A

  公开（公告）日：1997-01-28
• Synthesis and Phospholipase A₂ Inhibitory Activity of Thielocin B3 Derivatives
  作者：Isao Teshirogi、Shigeru Matsutani、Kazuhiro Shirahase、Yasuhiko Fujii、Tadashi Yoshida、Kazushige Tanaka、Mitsuaki Ohtani

  DOI：10.1021/jm960437a

  日期：1996.1.1

  We prepared several types of derivatives of thielocin B3, a very potent naturally occurring inhibitor for human nonpancreatic secretory PLA(2) (sPLA(2)-II), and conducted a structure-activity relationship study to identify potent sPLA(2)-II inhibitors with the aim of developing antiinflammatory drugs. The total number of aromatic rings is critical for sPLA(2)-II inhibition, and the best result was obtained in the case of six rings. The structure of the central part of the inhibitors was not specific, and potent inhibitors were found among the sulfide, sulfone, ether, methylene, and amino derivatives. Although a diester of the terminal carboxylic acid lost its inhibitory activity, having both of the carboxylic acids was not necessary for expression of activity, as illustrated by a glycine derivative with the benzyl ester group 36. Among the newly synthesized derivatives, 18, 20, 29, and 36 showed very potent human sPLA(2)-II inhibitory activity comparable to that of natural thielocin B3. Their IC50 values are in the range 0.069-0.14 mu M, and they are a class of compounds showing the most potent sPLA(2)-II inhibition to date.