N-乙基-3-哌啶胺 | 1249848-14-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: N-乙基-3-哌啶胺
• 英文名称: N-Ethylpiperidin-3-amine
• CAS: 1249848-14-3
• 化学式: C₇H₁₆N₂
• 分子量: 128.22
• InChiKey: FUTMGJAGTIOOIF-UHFFFAOYSA-N

物化性质

• 沸点：
  186℃
• 密度：
  0.90
• 闪点：
  67℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROARYLES SERVANT D'INHIBITEURS D'IRAK, ET LEURS UTILISATIONS
  申请人：MERCK PATENT GMBH

  公开号：WO2016081679A1

  公开（公告）日：2016-05-26

  The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, useful as IRAK inhibitors.

  本发明涉及式I化合物或其药用可接受盐，用作IRAK抑制剂。
• [EN] NLRP3 MODULATORS<br/>[FR] MODULATEURS DE NLRP3
  申请人：INNATE TUMOR IMMUNITY INC

  公开号：WO2019014402A1

  公开（公告）日：2019-01-17

  The present invention provides compounds of Formula (I): (I) wherein all of the variables are as defined herein. These compounds are modulators of NLRP3, which may be used as medicaments for the treatment of proliferative disorders, such as cancer in a subject (e.g., a human).

  本发明提供了Formula (I)的化合物：(I)其中所有变量均如本文所定义。这些化合物是NLRP3的调节剂，可用作治疗增殖性疾病的药物，例如在受试者（例如人类）中的癌症治疗。
• [EN] ANTI-CANCER/ANTI-FIBROSIS COMPOUNDS<br/>[FR] COMPOSÉS ANTICANCÉREUX/ANTI-FIBROSE
  申请人：UNIV CALIFORNIA

  公开号：WO2019028059A1

  公开（公告）日：2019-02-07

  This invention provides, among other things, compounds useful for treating diseases such as fibrosis and/or cancer, pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.

  这项发明提供了用于治疗纤维化和/或癌症等疾病的化合物，含有这些化合物的药物配方，以及这些化合物与至少一种额外治疗剂的组合。
• Process for producing 1-alkoxycarbonyl nitrogenous saturated heterocyclic derivative
  申请人：——

  公开号：US20040242888A1

  公开（公告）日：2004-12-02

  A method for producing N-protected heterocyclic compounds such as 1-alkoxycarbonyl-3-aminopyrrolidines through position-selective reaction at the nitrogen atom that constitutes the hetero ring of a nitrogen-containing saturated heterocyclic compound having two nitrogen atoms such as 3-aminopyrrolidine. A dialkyl dicarbonate (ROCO-O-COOR) is reacted with a nitrogen-containing saturated heterocyclic compounds having two nitrogen atoms, at pH of from 9 to 14 to obtain a high-purity 1-alkoxycarbonyl nitrogen-containing saturated heterocyclic compound.

  一种生产N-保护杂环化合物（例如1-烷氧羰基-3-氨基吡咯烷）的方法，通过在含有两个氮原子的氮杂环化合物（例如3-氨基吡咯烷）的杂环中构成氮原子的位置选择性反应。将双烷基碳酸酯（ROCO-O-COOR）与含有两个氮原子的氮杂环化合物在pH为9至14的条件下反应，可获得高纯度的1-烷氧羰基氮杂环化合物。
• 1,7-DIAZACARBAZOLES AND METHODS OF USE
  申请人：Dyke Hazel Joan

  公开号：US20110183938A1

  公开（公告）日：2011-07-28

  The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  该发明涉及1,7-二氮杂咔唑化合物的公式（I）、（I-a）和（I-b），它们可用作激酶抑制剂，更具体地用作检查点激酶1（CHK1）抑制剂，因此可用作癌症治疗剂。该发明还涉及包含这些化合物的组合物，更具体地是药物组合物，以及使用它们治疗各种癌症和高增殖性疾病的方法，以及使用这些化合物进行哺乳动物细胞的体外、原位和体内诊断或治疗，或相关病理条件的方法。