7N-Methyl-8-hydroguanosine-5'-triphosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 7N-Methyl-8-hydroguanosine-5'-triphosphate
• 英文别名: [[(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1,8-dihydropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C₁₁H₂₀N₅O₁₄P₃
• 分子量: 539.22
• InChiKey: BUJQMJUTTBGELS-KQYNXXCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.1
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  288
• 氢给体数：
  8
• 氢受体数：
  19

文献信息

• STEROL PURIFICATION
  申请人：ModernaTX, Inc.

  公开号：US20210347810A1

  公开（公告）日：2021-11-11

  The invention relates to sterol esters and methods for producing purified sterols that can be utilized in methods for producing a lipid nanoparticle.

  本发明涉及甾醇酯和生产纯化甾醇的方法，这些甾醇可以用于生产脂质纳米粒子的方法。
• TRINUCLEOTIDE MRNA CAP ANALOGS
  申请人：ModernaTX, Inc.

  公开号：US20190211368A1

  公开（公告）日：2019-07-11

  The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

  本公开涉及盖帽类似物，可以导致高水平的盖帽效率和转录以及改善翻译效率。本公开还涉及用于制备盖帽类似物和使用含有这种类似物的mRNA物种的有用方法，以及包含新型盖帽类似物的试剂盒。
• STEROL ANALOGS AND USES THEREOF
  申请人：ModernaTX, Inc.

  公开号：US20220402965A1

  公开（公告）日：2022-12-22

  The invention relates to compositions and methods for the preparation, manufacture, and therapeutic use of compositions comprising mRNA and a lipid nanoparticle comprising a compound of the invention and an ionizable lipid.

  本发明涉及包含mRNA和脂质纳米粒子的组合物的制备、制造和治疗用途的方法和组合物，所述脂质纳米粒子包括本发明的化合物和可离子化脂质。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• Soluble fragments of influenza virus PB2 protein capable of binding RNA-cap
  申请人：European Molecular Biology Laboratory

  公开号：EP2574619A2

  公开（公告）日：2013-04-03

  The present invention relates to soluble fragments of the Influenza virus RNA dependent RNA polymerase subunit PB2 and variants thereof, and crystallized complexes thereof comprising an RNA cap analog. This invention also relates to computational methods using the structural coordinates of said complex to screen for and design compounds that interact with the RNA cap binding pocket. In addition, this invention relates to methods identifying compounds that bind to PB2 polypeptide fragments comprising the RNA cap binding pocket, preferably inhibit the interaction with RNA caps or analogs thereof, by using said PB2 polypeptide fragments, preferably in a high-throughput setting. This invention also relates to compounds and pharmaceutical compositions comprising the identified compounds for the treatment of disease conditions due to viral infections caused by negative-sense single stranded RNA viruses.

  本发明涉及流感病毒 RNA 依赖性 RNA 聚合酶亚基 PB2 的可溶性片段及其变体，以及包含 RNA 帽类似物的结晶复合物。本发明还涉及使用所述复合物的结构坐标来筛选和设计与 RNA 帽结合口袋相互作用的化合物的计算方法。此外，本发明还涉及通过使用所述 PB2 多肽片段，最好是在高通量环境下，鉴定与包含 RNA帽结合口袋的 PB2 多肽片段结合的化合物，最好是抑制与 RNA帽或其类似物相互作用的化合物的方法。本发明还涉及用于治疗由负义单链 RNA 病毒引起的病毒感染所致疾病的化合物和包含所鉴定化合物的药物组合物。