N-[4-(dimethylamino)phenyl]dibenzo[b,d]furan-2-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: N-[4-(dimethylamino)phenyl]dibenzo[b,d]furan-2-sulfonamide
• 英文别名: N-[4-(dimethylamino)phenyl]dibenzofuran-2-sulfonamide
• 化学式: C₂₀H₁₈N₂O₃S
• mdl: MFCD06016977
• 分子量: 366.4
• InChiKey: AWIDDVSYPUPGCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  70.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] SULPHONAMIDE DERIVATIVES<br/>[FR] DERIVES SULFONAMIDES
  申请人：BIOTIE THERAPIES CORP

  公开号：WO2005090298A1

  公开（公告）日：2005-09-29

  The invention relates to sulphonamide derivatives of formula (I), where RC is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or RC forms together with the phenyl ring to which it is attached a benzodioxolyl group, or RC is -NR1R2, RA is a group having the formula (A), (B) or (C) RB is hydrogen or alkyl. The invention also relates to the use of derivatives of formula (I) as inhibitors for collagen receptor integrins and a process for preparing sulphonamides of formula (I).

  这项发明涉及式(I)的磺胺衍生物，其中RC是可选择取代的含有一个或多个N原子的4-6元杂环环，或者RC与其连接的苯环一起形成苯二氧杂环基团，或者RC是-NR1R2，RA是具有式(A)、(B)或(C)的基团，RB是氢或烷基。该发明还涉及将式(I)的衍生物用作胶原受体整合素的抑制剂以及制备式(I)的磺胺衍生物的方法。
• Sulphonamide Derivatives
  申请人：Smith David

  公开号：US20080255169A1

  公开（公告）日：2008-10-16

  The invention relates to sulphonamide derivatives of formula (I), where R C is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or R C forms together with the phenyl ring to which it is attached a benzodioxolyl group, or R C is —NR 1 R 2 , R A is a group having the formula R B is hydrogen or alkyl. The invention also relates to the use of derivatives of formula (I) as inhibitors for collagen receptor integrins and a process for preparing sulphonamides of formula (I).

  该发明涉及式(I)的磺胺基衍生物， 其中 R C 是可选取代的含有一个或多个N原子的4-6元杂环环，或 R C 与其连接的苯环一起形成苯二氧杂基团，或 R C 是-NR 1 R 2 ， R A 是具有式的基团 R B 是氢或烷基。 该发明还涉及将式(I)的衍生物用作胶原受体整合素的抑制剂以及制备式(I)的磺胺基的方法。