schisanwilsonin A

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: schisanwilsonin A
• 英文别名: gomisin B；Arisanschinin N；[(8S,9R,10S)-9-hydroxy-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-8-yl] (Z)-2-methylbut-2-enoate
• 化学式: C₂₈H₃₄O₉
• 分子量: 514.573
• InChiKey: BKGUPIVDQHHVMV-ZQJDBEKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• ATR INHIBITOR
  申请人：Niigata TLO Corporation

  公开号：EP1946757A1

  公开（公告）日：2008-07-23

  The present invention is to provide ATR inhibitor containing tricyclic compound including Schizandrins and Gomisins as an active constituent, useful for an inhibitor of ATR protein kinase.

  本发明旨在提供一种 ATR 抑制剂，其活性成分中含有三环化合物，包括 Schizandrins 和 Gomisins，可用于 ATR 蛋白激酶抑制剂。
• ATR Inhibitor
  申请人：Nishida Hiroshi

  公开号：US20100048923A1

  公开（公告）日：2010-02-25

  The present invention is to provide ATR inhibitor containing tricyclic compound including Schizandrins and Gomisins as an active constituent, useful for an inhibitor of ATR protein kinase.
• RADIOSENSITIZER COMPOSITIONS COMPRISING SCHISANDRA CHINENSIS(TURCZ.)BAILL AND METHODS FOR USE
  申请人：LAI I Cheng

  公开号：US20110124741A1

  公开（公告）日：2011-05-26

  The present invention provides a method of potentiating radiation therapy for treatment of a cancer or tumor comprising administrating to a subject in need thereof a therapeutically effective amount of a radiosensitizer in combination of a radiation therapy to a locus of the cancer or tumor, wherein the radiosensitizer is an extract of Schisandra chinensis (Turcz.) Baill, or the active ingredient isolated therefrom, particularly Schisandrin B.
• SCHISANDRA SPHENANTHERA FRUIT EXTRACT AND COSMETIC, DERMATOLOGICAL AND NUTRACEUTICAL COMPOSITIONS COMPRISING SAME
  申请人：Garnier Sebastien

  公开号：US20120121743A1

  公开（公告）日：2012-05-17

  The present invention relates to a cosmetic, dermatological or nutraceutical composition comprising a Schisandra sphenanthera fruit extract. Said Schisandra sphenanthera fruit extract is selected from a peptide and sugar extract, a crude oil, a refined oil, a refined oil concentrate or the unsaponifiable fraction of said concentrate. The invention also relates to a method for preparing a peptide and sugar extract, a refined oil, and a concentrate and an unsaponifiable fraction of oil of Schisandra sphenanthera fruit. Finally, the invention relates to the dermatological, cosmetic and nutraceutical uses of said extracts.
• US8586107B2
  申请人：——

  公开号：US8586107B2

  公开（公告）日：2013-11-19