Pyrido-[2,3-d]-pyrimidin-7-one 35

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Pyrido-[2,3-d]-pyrimidin-7-one 35
• 英文别名: 6-bromo-8-cyclopentyl-5-methyl-2-(4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-one
• 化学式: C₂₃H₂₇BrN₆O
• 分子量: 483.4
• InChiKey: NTQUCCVMCHSPRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  73.4
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1268476A1

  公开（公告）日：2003-01-02
• [EN] 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE TYROSINE KINASE A BASE DE 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES
  申请人：WARNER LAMBERT CO

  公开号：WO2001070741A1

  公开（公告）日：2001-09-27

  Disclosed are compounds of the formula (I) wherein: R2 is hydrogen, alkyl, or cycloalkyl; R3 is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkynyl, lower alkenyl, nitrile, nitro, -COR4, -CO2R?4, -CONR4R5, -CONR4OR5, -SO¿2NR?4R5, -SO¿2NR?4R5, -SO¿2R4, -SO3R4, formula (II), or -NR4R5; Y is N or CR7; R9 is lower alkyl, haloalkyl, or aryl; X and Z are independently hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, nitrile, nitro, -NR4R5, -N(O)R?4R5, -NR4R5R6W, -SR4¿, -C(O)R4, -CO2R?4, -CONR4R5, -SO¿2NR?4R5, -SO¿2R4, -SO3R4, P(O)(OR4)(OR5), -T(CH¿2)mQR?4, -C(O)T(CH¿2)mQR?4, or -NR4C(O)T(CH¿2)mQR?5; m is 1 to 6. These compounds are useful for treating cell proliferative disorders, such as cancer, atherosclerosis, and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases.