1-[(5-Bromo-2-methoxyphenyl)methyl]-4-(2-fluorophenyl)piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[(5-Bromo-2-methoxyphenyl)methyl]-4-(2-fluorophenyl)piperazine
• 化学式: C₁₈H₂₀BrFN₂O
• 分子量: 379.3
• InChiKey: GZLYIAJCYJDZQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• COMPOUNDS FOR MODULATING T-CELLS
  申请人：Trede Nikolaus S.

  公开号：US20080293739A1

  公开（公告）日：2008-11-27

  Disclosed are compounds and compositions that modulate T-cells. Such compounds can be used to treat T-cell mediated disease like T-ALL, rheumatoid arthritis, multiple sclerosis, and graft-vs-host disease (GvHD), to name but a few. The compounds have a general structure as shown in Formula I. Ar 1 -L-Ar 2 I wherein Ar 1 and Ar 2 , are independent of one another, a substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl; and L is a bond or a linker spanning two, three, four, or five atoms.
• US8039505B2
  申请人：——

  公开号：US8039505B2

  公开（公告）日：2011-10-18