N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide
• 英文别名: N-[(E)-1,3-dihydroxyoctadec-4-en-2-yl]octanamide
• 化学式: C₂₆H₅₁NO₃
• 分子量: 425.7
• InChiKey: APDLCSPGWPLYEQ-XUTLUUPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  30
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] BRANCHED PEG MOLECULES AND RELATED COMPOSITIONS AND METHODS<br/>[FR] MOLÉCULES DE PEG RAMIFIÉ, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
  申请人：PHASERX INC

  公开号：WO2018126084A1

  公开（公告）日：2018-07-05

  Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.

  揭示了分支聚乙二醇（PEG）分子，包括分支PEG-脂质和分支PEG-蛋白质，以及制备分支PEG分子的相关组合物和方法。还公开了相关的组合物、系统和方法，用于体内传递治疗和诊断试剂。
• Cermide Kinase Modulation
  申请人：Bornancin Frederic

  公开号：US20090170914A1

  公开（公告）日：2009-07-02

  A compound of formula (I) wherein R 1 is a straight chain, branched or cyclic aliphatic, aromatic or heterocyclyl group comprising at least 8 carbon atoms, e.g. 8 to 22, R 2 is a straight chain, branched or cyclic aliphatic, aromatic or heterocyclic group comprising from 1 to 12 carbon atoms, and ring A is heterocycyl, fused with the phenyl ring to which ring A is attached comprising 5 or 6 ring members, and 1 to 4 heteroatoms selected from N, S, O; wherein certain compounds are excluded by proviso and the use of such compounds without proviso as pharmaceuticals in disorders which are mediated by ceramide kinase.

  式（I）的化合物中，其中R1是直链、支链或环状的脂肪族、芳香族或杂环基团，含有至少8个碳原子，例如8到22个碳原子；R2是直链、支链或环状的脂肪族、芳香族或杂环基团，含有1到12个碳原子；环A是杂环基团，与环A连接的苯环融合，包括5个或6个环成员和1到4个N、S、O中选择的杂原子；其中通过约定排除了某些化合物，并且在没有约定的情况下使用这些化合物作为通过神经酰胺激酶介导的疾病的药物。
• Functional associative coatings for nanoparticles
  申请人：Hainfeld James F.

  公开号：US20080089836A1

  公开（公告）日：2008-04-17

  Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

  本文描述了一种纳米颗粒，其表面涂覆有由表面结合分子和两亲分子形成的双层分子层。该双层涂层可以自组装在纳米颗粒上，使用易得的材料/分子。双层涂层纳米颗粒的模块化设计提供了一种方便和高效地优化其性质的方法。此外，本文还描述了这种纳米颗粒在医学、实验室技术、工业和商业应用中的用途。
• Antiviral medicament and method for producing and using the same for the prophylactic and therapeutic treatment of papillomavirus induced tumors, lesions and deseases
  申请人：——

  公开号：US20040109899A1

  公开（公告）日：2004-06-10

  There is disclosed a prophylactic and therapeutic antiviral composition and in particular compositions which comprise containing vertebrates kidney as a main component. Use of the composition through parenteral administration for the prevention and treatment of viral-induced tumors, lesions and diseases in mammals such as humans or to prepare a medicament is also disclosed. The composition is very effective in preventing and treating viral infections and manifestations as hyperplasia, keratosis, and dermatosis and in particular those caused by Papillomavirus and more particularly Human Papillomavirus. Among the many benefits, the present compounds provide high remedial effect and complete resolution in a relatively short course of treatment with no risk of side effects what so ever. The composition is abundant, inexpensive, easily prepared, and may be self administered to the afflicted area by the patients themselves.

  本发明公开了一种预防性和治疗性抗病毒组合物，特别是以脊椎动物肾脏为主要成分的组合物。还公开了通过肠外给药使用该组合物预防和治疗病毒引起的哺乳动物（如人类）肿瘤、病变和疾病或制备药物的方法。本组合物在预防和治疗病毒感染和增生、角化病和皮肤病等表现方面非常有效，特别是由乳头瘤病毒，尤其是人类乳头瘤病毒引起的感染和表现。在众多优点中，本化合物具有很高的治疗效果，在相对较短的疗程内就能彻底解决问题，而且没有任何副作用的风险。本发明的成分丰富，价格低廉，易于制备，可由患者自行施用到患病部位。
• Ceramide de novo synthesis-based therapeutic and prophylactic methods, and related articles of manufacture
  申请人：Worgall S. Tilla

  公开号：US20050182020A1

  公开（公告）日：2005-08-18

  Described is a method for decreasing the amount of mSREBP in a cell characterized by an elevated level of mSREBP comprising contacting the cell with an agent that specifically inhibits de novo synthesis of ceramide in the cell, thereby decreasing the amount of mSREBP in the cell. Also described are related methods and articles of manufacture.

  描述了一种降低细胞中 mSREBP 含量的方法，其特征是细胞中 mSREBP 含量升高，该方法包括使细胞与特异性抑制细胞中神经酰胺从头合成的制剂接触，从而降低细胞中 mSREBP 的含量。还描述了相关的制造方法和物品。