6-Ethyl-7-hydroxy-4-phenyl-8-pyrrolidin-1-ylmethyl-chromen-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 6-Ethyl-7-hydroxy-4-phenyl-8-pyrrolidin-1-ylmethyl-chromen-2-one
• 英文别名: 6-ethyl-7-hydroxy-4-phenyl-8-(pyrrolidin-1-ylmethyl)-2H-chromen-2-one；6-ethyl-7-hydroxy-4-phenyl-8-(pyrrolidin-1-ylmethyl)chromen-2-one
• 化学式: C₂₂H₂₃NO₃
• mdl: MFCD02338723
• 分子量: 349.43
• InChiKey: NZYIMYYVGKUQJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(吡咯烷-1-基甲基)吡咯烷 、 6-ethyl-7-hydroxy-4-phenyl-coumarin 以 1,4-二氧六环 为溶剂， 以71%的产率得到6-Ethyl-7-hydroxy-4-phenyl-8-pyrrolidin-1-ylmethyl-chromen-2-one
  参考文献：
  名称：

  摘要：

  Aminomethylation of 5-hydroxy- and 7-hydroxy-4-phenylcoumarins by substituted 1, 1-dianzinomethanes is studied Mannich condensation of amino acids and their esters with 7-hydroxy-4-phenylcoumarin gives a series of 8-aminoacylmethylcoumarins and 4-phenyl-9, 10-dihydro-2H, 8H-chromeno[8, 7-e][1, 3]oxazin-2-ones.

  DOI：

  10.1023/a:1002835422747

文献信息

• [EN] ANTI-CANCER COMPOUNDS<br/>[FR] COMPOSÉS ANTI-CANCEREUX
  申请人：UNIV TEXAS

  公开号：WO2015010032A1

  公开（公告）日：2015-01-22

  Provided are methods and compositions for the treatment of diseases such as cancer. In certain aspects, compounds which can inhibit Skp2 are provided. Specifically chromenone derivatives are disclosed that have the capability toward reducing differentiation of pluripotent, multipotent or totipotent cells and thus have therapeutic utility in the treatment of a proliferative disease such as cancer.

  提供了治疗癌症等疾病的方法和组合物。在某些方面，提供了可以抑制Skp2的化合物。具体地，披碱酮衍生物被揭示具有减少多能、多潜能或全能细胞分化的能力，因此在治疗癌症等增生性疾病中具有治疗效用。
• ANTI-CANCER COMPOUNDS
  申请人：BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

  公开号：US20160145250A1

  公开（公告）日：2016-05-26

  Provided are methods and compositions for the treatment of diseases such as cancer. In certain aspects, compounds which can inhibit Skp2 are provided. Specifically chromenone derivatives are disclosed that have the capability toward reducing differentiation of pluripotent, multipotent or totipotent cells and thus have therapeutic utility in the treatment of a proliferative disease such as cancer.
• US9624211B2
  申请人：——

  公开号：US9624211B2

  公开（公告）日：2017-04-18
• ——
  作者：M. M. Garazd、Ya. L. Garazd、S. V. Shilin、V. P. Khilya

  DOI：10.1023/a:1002835422747

  日期：——

  Aminomethylation of 5-hydroxy- and 7-hydroxy-4-phenylcoumarins by substituted 1, 1-dianzinomethanes is studied Mannich condensation of amino acids and their esters with 7-hydroxy-4-phenylcoumarin gives a series of 8-aminoacylmethylcoumarins and 4-phenyl-9, 10-dihydro-2H, 8H-chromeno[8, 7-e][1, 3]oxazin-2-ones.