2-chloro-4-[(2S)-2-methylpiperazin-1-yl]benzonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-chloro-4-[(2S)-2-methylpiperazin-1-yl]benzonitrile
• 化学式: C₁₂H₁₄ClN₃
• 分子量: 235.71
• InChiKey: BNWVDRNYSCCNBJ-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  39.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Ureas having androgen receptor degradation activity and uses thereof
  申请人：ACCUTAR BIOTECHNOLOGY INC.

  公开号：US11220490B2

  公开（公告）日：2022-01-11

  The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity.

  本公开涉及新型化合物、含有此类化合物的药物组合物及其在预防和治疗癌症及相关疾病和病症中的用途。在某些实施方案中，本文公开的化合物具有雄激素受体降解活性。
• NOVEL UREAS HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF
  申请人：ACCUTAR BIOTECHNOLOGY INC.

  公开号：US20210300901A1

  公开（公告）日：2021-09-30

  The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity.
• [EN] NOVEL UREAS HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF<br/>[FR] NOUVELLES URÉES AYANT UNE ACTIVITÉ DE DÉGRADATION DU RÉCEPTEUR DES ANDROGÈNES ET LEURS UTILISATIONS
  申请人：ACCUTAR BIOTECHNOLOGY INC

  公开号：WO2021061642A1

  公开（公告）日：2021-04-01

  The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity.