利福霉素类药
利福霉素类抗生素由地中海链丝菌产生，具有广谱抗菌作用，尤其对结核杆菌、麻风杆菌、链球菌和肺炎球菌等革兰氏阳性细菌，特别是耐药性金黄色葡萄球菌表现出很强的效果。此外，它们也对某些革兰氏阴性菌有效。
利福霉素类药物包括利福霉素B二乙酰胺和利福平等。目前临床应用的主要有利福平、利福喷汀及利福布汀。其中，利福平是药效最好且应用最广泛的一种，不仅抗菌谱广，适用于多种细菌感染性疾病，而且与其他药物之间无交叉抗药性，对结核病的疗效尤为显著，因此被列为治疗结核病的一线药物。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| 利福霉素 | rifamycin SV | 6998-60-3 | C37H47NO12 |
|
| 利福霉素 | rifamycin S | 13553-79-2 | C37H45NO12 |
|
| 利福西亚胺 | rifaximin | 80621-81-4 | C43H51N3O11 |
|
| 利福美坦 | 3-[(1-diethylaminoethylidene)azinomethyl]rifamycin SV | 94168-98-6 | C44H60N4O12 |
|
| 利福平苯醌 | rifampicin quinone | 13983-13-6 | C43H56N4O12 |
|
| 利福平 | rifampicin | 13292-46-1 | C43H58N4O12 |
|
| 利福喷丁 | [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-[(4-cyclopentylpiperazin-1-yl)iminomethyl]-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 61379-65-5 | C47H64N4O12 |
|
| 利福克昔 | Rifamexil | 113102-19-5 | C42H55N3O11S |
|
| 二恶酮利福霉素 | rifamycin O | 14487-05-9 | C39H47NO14 |
|
| 3甲酰利福平霉素 | 3-formylrifamycin SV | 13292-22-3 | C38H47NO13 |
|
| —— | Rifaximin (Xifaxan) | 80621-81-4 | C43H51N3O11 |
|
| —— | rifamycin B | 2750-76-7 | C43H58N2O13 |
|
| —— | Rifamid | 2750-76-7 | C43H58N2O13 |
|
| —— | Rifomycin B diethylamide | 2750-76-7 | C43H58N2O13 |
|
| —— | Rifamycins | 13553-79-2 | C37H45NO12 |
|
| —— | 3-(4-Isobutyl-1-piperazinyl)-rifamycin SV | 57184-22-2 | C45H63N3O12 |
|
| —— | 2,7-(Epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione,25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-,(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)- | 80621-81-4 | C43H51N3O11 |
|
| —— | Rifomycin O | 14487-05-9 | C39H47NO14 |
|
| —— | 3-amino-<i>O</i><sup>1</sup>,<i>O</i><sup>4</sup>-didehydro-rifamycin | 51756-80-0 | C37H46N2O12 |
|
| —— | 3-aminorifamycin S | 51756-80-0 | C37H46N2O12 |
|
| —— | Rifomycins | 13553-79-2 | C37H45NO12 |
|
| —— | [(7R,9E,11S,12R,13S,14R,15R,16S,17S,18R,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1(35),2,4,9,19,21,25(36),26(34),28,30,32-undecaen-13-yl] acetate | 80621-81-4 | C43H51N3O11 |
|
| —— | Rifapentine | 61379-65-5 | C47H64N4O12 |
|
| —— | Mycobutin | 72559-06-9 | C46H62N4O11 |
|
| —— | 1-b]Furan-21-yl acetate | 13292-46-1 | C43H58N4O12 |
|
| —— | [(7S,11S,12R,13S,14R,15R,16R,17S,18S)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 13292-46-1 | C43H58N4O12 |
|
| —— | [(7S,9E,11S,12R,13R,14R,15R,16R,17S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 13292-46-1 | C43H58N4O12 |
|
| —— | rifapentine hydrochloride | 127923-87-9 | C47H64N4O12*ClH |
|
| —— | [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-[(Z)-(4-cyclopentylpiperazin-1-yl)iminomethyl]-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 61379-65-5 | C47H64N4O12 |
|
| —— | [(7S,11S,12R,13S,14R,15R,16R,17S,18S)-26-[(4-cyclopentylpiperazin-1-yl)iminomethyl]-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 61379-65-5 | C47H64N4O12 |
|
| —— | [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21E)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 13292-46-1 | C43H58N4O12 |
|
| —— | [(7S,11S,12R,13S,14R,15R,16R,17S,18S)-26-[(E)-(4-cyclopentylpiperazin-1-yl)iminomethyl]-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 61379-65-5 | C47H64N4O12 |
|
| —— | [(7S,9E,11S,12R,13R,14R,15R,16R,17S,18S,19E,21E)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 13292-46-1 | C43H58N4O12 |
|
| —— | Pharmakon1600-01500529 | 13292-46-1 | C43H58N4O12 |
|
| —— | Rifampin;Rifamycin AMP | 13292-46-1 | C43H58N4O12 |
|
| —— | [(7S,9E,12R,13S,16R,17S)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(Z)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 13292-46-1 | C43H58N4O12 |
|
| —— | [(7S,11S,12R,13S,14R,15R,16R,17S,18S)-2,6,15,17-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-30-[4-(2-methylpropyl)piperazin-1-yl]-23,32,37-trioxo-8,27,38-trioxa-24,34-diazahexacyclo[23.11.1.14,7.05,36.026,35.028,33]octatriaconta-1,3,5,9,19,21,25,28,30,33,35-undecaen-13-yl] acetate | 129791-92-0 | C51H64N4O13 |
|
| —— | [(9Z,19Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 13292-46-1 | C43H58N4O12 |
|
| —— | [(7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(Z)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 13292-46-1 | C43H58N4O12 |
|
| —— | [(7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 13292-46-1 | C43H58N4O12 |
|
| —— | Rifampicin,(S) | 13292-46-1 | C43H58N4O12 |
|
| —— | [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 13292-46-1 | C43H58N4O12 |
|
| —— | [(9E,19E)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1(35),2,4,9,19,21,25(36),26(34),28,30,32-undecaen-13-yl] acetate | 80621-81-4 | C43H51N3O11 |
|
| —— | [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21E)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(Z)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate | 13292-46-1 | C43H58N4O12 |
|
| —— | Rifamycin S | 13553-79-2 | C37H45NO12 |
|
| —— | 2'-(N,N-diethylamino)rifamycin P | 113102-19-5 | C42H55N3O11S |
|
| —— | rifamycin sodium | 14897-39-3 | C37H46NO12*Na |
|
| —— | 1',4-didehydro-1-desoxi-1,4-di-hydro-5'-(2-methyl-propyl)-1-oxo-rifamycin | 72559-06-9 | C46H62N4O11 |
|
| —— | Rifalazil | 129791-92-0 | C51H64N4O13 |
|
| —— | Rifampicin | 13292-46-1 | C43H58N4O12 |
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