Shiraiachrome B | 124709-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苝醌类
• 英文名称: Shiraiachrome B
• 英文别名: 14-acetyl-7,13,19-trihydroxy-5,10,16,21-tetramethoxy-13-methylhexacyclo[13.8.0.0²,¹¹.0³,⁸.0⁴,²².0¹⁸,²³]tricosa-1,3,5,7,10,15,18(23),19,21-nonaene-9,17-dione；hypocrellin A；Hypocrellin；shiraiachrome A
• CAS: 124709-39-3
• 化学式: C30H26O10
• InChiKey: BQJKVFXDDMQLBE-UHFFFAOYSA-N

物化性质

• 沸点：
  922.8±65.0 °C(Predicted)
• 密度：
  1.55±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.32
• 重原子数：
  40.0
• 可旋转键数：
  5.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  148.82
• 氢给体数：
  3.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  Shiraiachrome B 在 potassium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 36.0h， 生成
  参考文献：
  名称：

  含长链季铵盐的竹红菌素衍生物及其制备方法和应用

  摘要：

  本发明公开一种含长链季铵盐的竹红菌素衍生物及其制备方法和应用。所述衍生物的结构通式如式(1)或式(2)所示：其中，X为N、O或S；2≤m≤20，0≤n≤10，1≤p≤2，m、n、p均为正整数；R1、R2和R3分别为含1-20个碳原子的烷基；HA为竹红菌甲素；HB为竹红菌乙素。本发明首次采用长链的季铵盐来修饰竹红菌素，增强其水溶性和生物相容性，该类衍生物具有良好的脂水双亲性，可有效的结合生物体内负电荷物种，尤其是对肿瘤细胞具有很好的亲核性。该类带长链季铵盐竹红菌素衍生物可直接溶于生理盐水做成制剂药，提高药用效果，为开发竹红菌素类治疗癌症和抗癌病毒的药物提供可能。

  公开号：

  CN105541647A

文献信息

• Method for reduction of autofluorescence from biological samples
  申请人：Leica Microsystems CMS GmbH

  公开号：US11415516B2

  公开（公告）日：2022-08-16

  The invention discloses a method for reduction of autofluorescence in biological samples, comprising the steps of: a) providing a biological microscopy sample; b) irradiating the sample with visible light, wherein the visible light has a spectrum such that at least 50% of the light intensity emanates from a narrow wavelength interval within the visible range. The invention also discloses a method for autofluorescence reduction with triplet sensitizers irradiated with visible light.

  本发明公开了一种减少生物样品中自发荧光的方法，包括以下步骤： a) 提供生物显微镜样本； b) 用可见光照射样品，其中可见光的光谱使得至少 50%的光强来自可见光范围内的窄波长区间。本发明还公开了一种用可见光照射三重敏化剂减少自发荧光的方法。
• Spectroscopic studies on the interaction of Ga3+-hypocrellin A with myoglobin
  作者：Wenli Xie、Shaohua Wei、Jihua Liu、Xuefeng Ge、Lin Zhou、Jiahong Zhou、Jian Shen

  DOI：10.1016/j.saa.2013.10.085

  日期：2014.3

  In this article, the interaction mechanism of Ga3+-hypocrellin A (Ga3+-EA) with myoglobin (Mb) is studied in detail through various spectroscopic technologies. UV-vis absorption and fluorescence spectra demonstrate the interaction process. The Stern-Volmer plot and the time-resolved fluorescence study suggest the fluorescence quenching mechanism of Mb by Ga3+-HA is a static quenching procedure, and the electronic transfer forces play a major role in binding Ga3+-HA to Mb. Furthermore, synchronous fluorescence studies and circular dichroism (CD) spectra reveal that the conformation of Mb is changed after its conjugation with Ga3+-HA. (C) 2013 Elsevier B.V. All rights reserved.
• Excited-State Intramolecular H Atom Transfer of Hypericin and Hypocrellin A Investigated by Fluorescence Upconversion
  作者：A. V. Smirnov、K. Das、D. S. English、Z. Wan、G. A. Kraus、J. W. Petrich

  DOI：10.1021/jp992436a

  日期：1999.10.1

  The excited-state intramolecular H atom transfer reaction occurring in hypericin and hypocrellin A is investigated by means of the fluorescence upconversion technique in a variety of solvents. Rising components of similar to 10 ps, attributable to intramolecular H atom transfer, are Clearly observed in the fluorescence upconversion traces of both hypericin and hypocrellin A. The amplitude of the rising component is emission wavelength dependent and occurs on the blue edge of the emission spectra. Neither in hypericin nor in hypocrellin A does this fluorescent component exhibit a deuterium isotope effect. This result identifies it with the similar to 10 ps component, also lacking a deuterium isotope effect, observed id hypericin in transient absorption measurements monitoring stimulated emission. The clear and complementary observation in fluorescence of the similar to 10 ps component in both hypericin and hypocrellin A is a crucial link in refining a unified model of the hypericin and hypocrellin photophysics that we first proposed in J. Phys. Chem. B 1998, 102, 6098.
• Combination of a Histological or Cytological Fixing Agent and One or More Photoactivatable Compounds of the Quinone Family, In Particular Hypericin, Hypocrellin A and Hypocrellin B
  申请人：Peltier Eric

  公开号：US20090047704A1

  公开（公告）日：2009-02-19

  The invention relates to the combination, in solution or in a kit, of a histological or cytological fixing solution and of one or more photoactivatable compounds of the family of quinones, in particular, hypericin, hypocrellin A and/or hypocrellin B. The invention also relates to a method for labeling cells or tissues by one or more photoactivatable compounds of the family of quinones, in which the cells or tissues in contact with a histological or cytological fixing solution are labeled, simultaneously or subsequently, by the photoactivatable compound(s) of the family of quinones.
• PERYLENEQUINONE DERIVATIVES AND USES THEREOF
  申请人：Sharma Sanjay K.

  公开号：US20100047178A1

  公开（公告）日：2010-02-25

  The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders.