5-(4-p-Tolyl-thiophen-3-yl)-1-trityl-1H-tetrazole | 146012-96-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5-(4-p-Tolyl-thiophen-3-yl)-1-trityl-1H-tetrazole
• 英文别名: 5-[4-(4-Methylphenyl)thiophen-3-yl]-1-trityltetrazole
• CAS: 146012-96-6
• 化学式: C₃₁H₂₄N₄S
• 分子量: 484.624
• InChiKey: BZWRDANBKCHYOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  71.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(4-p-Tolyl-thiophen-3-yl)-1-trityl-1H-tetrazole 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 四氯化碳 为溶剂， 生成 5-[4-(4-Bromomethyl-phenyl)-thiophen-3-yl]-1-trityl-1H-tetrazole
  参考文献：
  名称：

  INVESTIGATION OF BIOISOSTERS OF THE GROWTH HORMONE SECRETAGOGUE L-692,429.

  摘要：

  The synthesis and structure-activity relationships of several analogs of L-692,429 with modifications in the biaryl and tetrazole moieties are described and several derivatives were found to be equipotent or slightly more potent than L-692,429. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00216-3
• 作为产物：
  描述：

  三苯基氯甲烷 、 5-(4-(4-methylphenyl)-thien-3-yl)-tetrazole 在 三乙胺 作用下， 生成 5-(4-p-Tolyl-thiophen-3-yl)-1-trityl-1H-tetrazole
  参考文献：
  名称：

  INVESTIGATION OF BIOISOSTERS OF THE GROWTH HORMONE SECRETAGOGUE L-692,429.

  摘要：

  The synthesis and structure-activity relationships of several analogs of L-692,429 with modifications in the biaryl and tetrazole moieties are described and several derivatives were found to be equipotent or slightly more potent than L-692,429. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00216-3

文献信息

• Angiotensin II antagonists incorporating a substituted thiophene or furan
  申请人：MERCK & CO. INC.

  公开号：EP0512675A1

  公开（公告）日：1992-11-11

  Substituted imidazoles attached through a methylene bridge to novel substituted phenyl thiophene or phenyl furan derivative of the Formula I are useful as angiotensin II antagonists.

  通过亚甲基桥连接到式 I 的新型取代苯基噻吩或苯基呋喃衍生物上的取代咪唑可用作血管紧张素 II 拮抗剂。
• US5177074A
  申请人：——

  公开号：US5177074A

  公开（公告）日：1993-01-05
• US5198438A
  申请人：——

  公开号：US5198438A

  公开（公告）日：1993-03-30
• US5252574A
  申请人：——

  公开号：US5252574A

  公开（公告）日：1993-10-12
• INVESTIGATION OF BIOISOSTERS OF THE GROWTH HORMONE SECRETAGOGUE L-692,429.
  作者：Michael Ankersen、Bernd Peschke、Birgit Sehested Hansen、Thomas Kruse Hansen

  DOI：10.1016/s0960-894x(97)00216-3

  日期：1997.5

  The synthesis and structure-activity relationships of several analogs of L-692,429 with modifications in the biaryl and tetrazole moieties are described and several derivatives were found to be equipotent or slightly more potent than L-692,429. (C) 1997 Elsevier Science Ltd.