1-(4-bromo-benzyl)-4-(4-oct-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid hydroxyamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(4-bromo-benzyl)-4-(4-oct-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid hydroxyamide
• 英文别名: 1-(4-bromo-benzyl)-4-(4-oct-2-ynyloxy-benzenesulfonyl)-piperdine-4-carboxylic acid hydroxyamide；1-(4-Bromobenzyl)-4-(4-oct-2-ynyloxybenzenesulfonyl)piperdine-4-carboxylic acid hydroxyamide；1-[(4-bromophenyl)methyl]-N-hydroxy-4-(4-oct-2-ynoxyphenyl)sulfonylpiperidine-4-carboxamide
• 化学式: C₂₇H₃₃BrN₂O₅S
• 分子量: 577.539
• InChiKey: WGANCLOVDGTTMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-(4-bromobenzyl)-4-(4-oct-2-ynyloxybenzenesulfonyl)piperidine-4-carboxylic acid 以17%的产率得到1-(4-bromo-benzyl)-4-(4-oct-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid hydroxyamide
  参考文献：
  名称：

  Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors

  摘要：

  该式化合物有助于治疗关节炎、肿瘤转移、组织溃疡、异常伤口愈合、牙周病、骨病、糖尿病（胰岛素抵抗）和HIV感染。

  公开号：

  US06358980B1

文献信息

• ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS
  申请人：Wyeth Holdings Corporation

  公开号：EP1147085B1

  公开（公告）日：2005-11-16
• US6358980B1
  申请人：——

  公开号：US6358980B1

  公开（公告）日：2002-03-19
• US6753337B2
  申请人：——

  公开号：US6753337B2

  公开（公告）日：2004-06-22
• [EN] METHOD FOR THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE<br/>[FR] METHODE DE TRAITEMENT DE LA POLYKYSTOSE RENALE
  申请人：AMERICAN DYANAMID COMPANY

  公开号：WO2002083112A2

  公开（公告）日：2002-10-24

  The present invention provides a method for treating, inhibiting the progression of, or eradicating polycystic kidney disease of in a patient in need thereof which comprises providing to said patient an effective amount of a TACE inhibitor compound alone or in combination with an effective amount of an EGF receptor kinase inhibitor.
• Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
  申请人：American Cyanamid Company

  公开号：US06358980B1

  公开（公告）日：2002-03-19

  Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.

  该式化合物有助于治疗关节炎、肿瘤转移、组织溃疡、异常伤口愈合、牙周病、骨病、糖尿病（胰岛素抵抗）和HIV感染。