N-methyl-O-(4,4,5,5,5-pentafluoropentyl)-N-(4-n-propylamino-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)hydroxylamine | 1610534-43-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: N-methyl-O-(4,4,5,5,5-pentafluoropentyl)-N-(4-n-propylamino-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)hydroxylamine
• 英文别名: N-Methyl-O-(4,4,5,5,5-pentafluoro-pentyl)-N-(4-n-propylamino-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)-hydroxylamine；2-N-methyl-2-N-(4,4,5,5,5-pentafluoropentoxy)-6-N-propyl-4-N-prop-2-ynyl-1,3,5-triazine-2,4,6-triamine
• CAS: 1610534-43-4
• 化学式: C₁₅H₂₁F₅N₆O
• 分子量: 396.363
• InChiKey: NSZNZNJGMDQZCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  75.2
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  N-methyl-O-(4,4,5,5,5-pentafluoropentyl)-N-(4-n-propylamino-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)hydroxylamine 、 hydrochloric acid diethyl ether 、 O-tert-butyl-N-(4-n-propylamino-6-prop-2-ynylamino[1,3,5]triazin-2-yl)hydroxylamine hydrochloride 以to yield N-methyl-O-(4,4,5,5,5-pentafluoro-pentyl)-N-(4-n-propylamino-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)-hydroxylamine hydrochloride (104a) in quantitative yield的产率得到N-methyl-O-(4,4,5,5,5-pentafluoropentyl)-N-(4-n-propylamino-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)hydroxylamine hydrochloride
  参考文献：
  名称：

  NOVEL ORALLY BIOAVAILABLE BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME

  摘要：

  本发明包括用于预防和/或治疗呼吸控制疾病或疾病的组合物，适用于需要此类治疗的受试者。本发明还包括一种预防和/或治疗受试者呼吸系统疾病或疾病的方法，包括向受试者施用本发明的治疗有效量的组合物。本发明还包括一种预防不稳定或稳定受试者呼吸节律的方法，包括向受试者施用本发明的治疗有效量的组合物。

  公开号：

  US20150291597A1
• 作为产物：
  描述：

  6-chloro-N2-(prop-2-ynylamino)-N4-n-propylamino-1,3,5-triazine-2,4-diamine 、 N-methyl-O-(4,4,5,5,5-pentafluoro-pentyl)-hydroxylamine hydrochloride 、 O-ethyl-N-methyl-N-(4-n-propylamino-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)hydroxylamine 以to yield N-methyl-O-(4,4,5,5,5-pentafluoro-pentyl)-N-(4-n-propylamino-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)-hydroxylamine (103) in 40% yield的产率得到N-methyl-O-(4,4,5,5,5-pentafluoropentyl)-N-(4-n-propylamino-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)hydroxylamine
  参考文献：
  名称：

  NOVEL ORALLY BIOAVAILABLE BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME

  摘要：

  本发明包括用于预防和/或治疗呼吸控制疾病或疾病的组合物，适用于需要此类治疗的受试者。本发明还包括一种预防和/或治疗受试者呼吸系统疾病或疾病的方法，包括向受试者施用本发明的治疗有效量的组合物。本发明还包括一种预防不稳定或稳定受试者呼吸节律的方法，包括向受试者施用本发明的治疗有效量的组合物。

  公开号：

  US20150291597A1

文献信息

• [EN] NOVEL ORALLY BIOAVAILABLE BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME<br/>[FR] NOUVEAUX COMPOSÉS DE MODULATION DE RÉGULATION DE LA RESPIRATION ORALEMENT BIODISPONIBLES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：GALLEON PHARMACEUTICALS INC

  公开号：WO2014078575A2

  公开（公告）日：2014-05-22

  The present invention includes compositions that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention.