4-[furan-2-yl-methylene-amino]-6-methyl-3-thioxo-[1,2,4]-triazin-3,4-dihydro(2H)-5-one | 292053-21-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4-[furan-2-yl-methylene-amino]-6-methyl-3-thioxo-[1,2,4]-triazin-3,4-dihydro(2H)-5-one
• 英文别名: 4-(furan-2-ylmethylideneamino)-6-methyl-3-sulfanylidene-2H-1,2,4-triazin-5-one
• CAS: 292053-21-5
• 化学式: C₉H₈N₄O₂S
• 分子量: 236.254
• InChiKey: JCIODXDOCJZABZ-UHFFFAOYSA-N

物化性质

• 熔点：
  186.8 °C
• 沸点：
  341.5±34.0 °C(Predicted)
• 密度：
  1.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-[furan-2-yl-methylene-amino]-6-methyl-3-thioxo-[1,2,4]-triazin-3,4-dihydro(2H)-5-one 、 silver nitrate 、 三苯基膦 以 二氯甲烷 为溶剂， 以84%的产率得到[Ag(4-[furan-2-yl-methylene-amino]-6-methyl-3-thioxo-[1,2,4]-triazin-3,4-dihydro(2H)-5-one)(PPh3)2](NO3)
  参考文献：
  名称：

  新型AMTTO-亚胺-配体及其银（I）配合物的合成与表征：TAMTTO，[Ag 2（TAMMTO）4 ]（NO 3）2  ·4MeOH，[Ag（TAMTTO）（PPh 3）2 ]的晶体结构NO 3  ·1.5THF，[Ag（FAMTTO）（PPh 3）2 ] NO 3

  摘要：

  4-氨基-6-甲基-1,2,4-三嗪-硫酮-5-酮（AMTTO，1）与2-噻吩甲醛和2-呋喃甲醛的反应生成相应的亚胺基化合物6-甲基-4- [噻吩-2-基-亚甲基-氨基] -3-硫代-[1,2,4]-三嗪-3,4-二氢（2H）-5-one（TAMTTO，2）和4- [呋喃-2-基-亚甲基-氨基] -6-甲基-3-硫代-[1,2,4]-三嗪-3,4-二氢（2H）-5-one（FAMTTO，3）。用AgNO 3处理2得到配合物[Ag 2（TAMMTO）4 ]（NO 3）2  ·4MeOH（4），用2和3形成[Ag（PPh 3）2 ] NO。图3给出了配合物[Ag（TAMTTO）（PPh 3）2 ] NO 3  ·1.5THF（5）和[Ag（FAMTTO）（PPh 3）2 ] NO 3（6）。所有化合物均已通过元素分析，红外光谱和质谱进行了表征。化合物2和所有配合物已分别通过X射线衍射研究进行了表征。此外，通过31

  DOI：

  10.1016/j.ica.2004.01.027

文献信息

• Compositions and methods for stabilizing benzothiazole luciferin analogs
  申请人：PROMEGA CORPORATION

  公开号：US11136615B2

  公开（公告）日：2021-10-05

  Disclosed herein are compositions and methods for stabilizing a benzothiazole luciferin analog such as D-luciferin and 6-amino-D-luciferin. The compositions may include the benzothiazole luciferin analog, a thionucleobase compound of formula (I), and a liquid medium, in which the thionucleobase is present in an amount effective to stabilize the luminogenic composition against decomposition. The methods provided herein may stabilize the benzothiazole luciferin analog against decomposition by contacting the benzothiazole luciferin analog with an effective amount of the thionucleobase compound in the presence of a liquid medium. Also provided herein is a kit containing the composition.

  本文公开了稳定苯并噻唑荧光素类似物（如 D-荧光素和 6-氨基-D-荧光素）的组合物和方法。这些组合物可包括苯并噻唑荧光素类似物、式（I）的硫代核酸酯化合物和液体培养基，其中硫代核酸酯的含量可有效稳定发光组合物，防止其分解。本文提供的方法可通过在液体介质存在下使苯并噻唑荧光素类似物与有效量的硫代核酸酶化合物接触来稳定苯并噻唑荧光素类似物，防止其分解。本文还提供了一种含有该组合物的试剂盒。
• COMPOSITIONS AND METHODS FOR STABILIZING LUMINOGENIC SUBSTRATES
  申请人：Promega Corporation

  公开号：US20150337198A1

  公开（公告）日：2015-11-26

  Disclosed herein are compositions and methods for stabilizing a luminogenic substrate such as coelenterazine or a functional analog thereof. The functional analog may be furimazine. The composition may include the luminogenic substrate, a thionucleoside, and an organic solvent, in which the thionucleoside is present in an amount effective to stabilize the luminogenic composition against decomposition. The method provided herein stabilizes the luminogenic substrate against decomposition by contacting the luminogenic substrate with an effective amount of the thionucleoside in the presence of the organic solvent. Also provided herein is a kit containing the composition.
• COMPOSITIONS AND METHODS FOR STABILIZING BENZOTHIAZOLE LUCIFERIN ANALOGS
  申请人：PROMEGA CORPORATION

  公开号：US20190040449A1

  公开（公告）日：2019-02-07

  Disclosed herein are compositions and methods for stabilizing a benzothiazole luciferin analog such as D-luciferin and 6-amino-D-luciferin. The compositions may include the benzothiazole luciferin analog, a thionucleobase compound of formula (I), and a liquid medium, in which the thionucleobase is present in an amount effective to stabilize the luminogenic composition against decomposition. The methods provided herein may stabilize the benzothiazole luciferin analog against decomposition by contacting the benzothiazole luciferin analog with an effective amount of the thionucleobase compound in the presence of a liquid medium. Also provided herein is a kit containing the composition.
• US9676997B2
  申请人：——

  公开号：US9676997B2

  公开（公告）日：2017-06-13