6-methoxymethyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one | 68283-13-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 6-methoxymethyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one
• 英文别名: 6-Methoxymethyl-imidazo[1,5-d]-as-triazin-4(3H)-one；6-(methoxymethyl)-3H-imidazo[1,5-d][1,2,4]triazin-4-one
• CAS: 68283-13-6
• 化学式: C₇H₈N₄O₂
• 分子量: 180.166
• InChiKey: CCBICNZACWTJTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-methoxymethyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one 在 溴 作用下， 以 叔丁醇 为溶剂， 反应 0.5h， 以2%的产率得到8-Bromo-6-methoxymethyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one
  参考文献：
  名称：

  Imidazo[1,5-d][1,2,4]triazines as potential antiasthma agents

  摘要：

  By using inhibition of histamine release from antigen-challenged, sensitized human basophils as a means of identifying a potentially prophylactic drug for the treatment of asthma, a series of substituted imidazo[1,5-d][1,2,4]triazines were found, which were active. These compounds were prepared by treating imidazolecarboxaldehydes with excess Grignard agent and then oxidizing the resulting alcohols to ketones with Jones reagent. Pyrolysis of a mixture of ketone and methyl carbazate at 200 degrees C in diphenyl ether produced the desired imidazo[1,5-d][1,2,4]triazines. Those compounds with the greatest basophil activity were tested for in vivo activity in the mouse passive cutaneous anaphylaxis (PCA) and the guinea pig passive anaphylaxis tests. The best compounds, 1-ethyl-8-methyl-6-propylimidazo[1,5-d][1,2,4]triazin-4(3H)- one (4-17) and 1,8-dimethyl-6-propylimidazo[1,5-d][1,2,4]triazin-4-(3H)-one (4-16) were chosen for further study.

  DOI：

  10.1021/jm00149a029
• 作为产物：
  描述：

  3-{[2-(Methoxymethyl)-4-imidazolyl]methylene)carbazic acid ethyl ester 以 二苯醚 为溶剂， 生成 6-methoxymethyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one
  参考文献：
  名称：

  Substituted 3-(4-imidazolylmethylene)carbazic and thiocarbazic acid

  摘要：

  提供了3-(4-咪唑基亚甲基)咔巴酸酯和3-(4-咪唑基亚甲基)二硫咔巴酸酯，用作制备抑制酶环磷酸腺苷磷酸二酯酶的化合物的中间体。

  公开号：

  US04124766A1

文献信息

• Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
  申请人：American Cyanamid Company

  公开号：US04107307A1

  公开（公告）日：1978-08-15

  There is provided substituted imidazo[1,5-d]-as-triazine-4(3H)-ones and substituted imidazo[1,5-d]-as-triazin-4(3H)-thiones useful as inhibitors of the enzyme cyclic-AMP phosphodiesterase and as broad spectrum herbicides.

  提供了替代的咪唑[1,5-d]-嘧啶-4(3H)-酮和替代的咪唑[1,5-d]-嘧啶-4(3H)-硫酮，可用作环磷酸腺苷磷酸二酯酶的抑制剂和广谱除草剂。
• Substituted 3-(4-imidazolylmethylene)carbazic and thiocarbazic acid
  申请人：American Cyanamid Company

  公开号：US04124766A1

  公开（公告）日：1978-11-07

  There are provided substituted 3-(4-imidazolyl-methylene)carbazic acid esters and 3-(4-imidazolylmethylene)dithiocarbazic acid esters useful as intermediates for the preparation of compounds which inhibit the enzyme cyclic-AMP phosphodiesterase.

  提供了3-(4-咪唑基亚甲基)咔巴酸酯和3-(4-咪唑基亚甲基)二硫咔巴酸酯，用作制备抑制酶环磷酸腺苷磷酸二酯酶的化合物的中间体。
• Apple tree named ‘Gala 0502B’
  申请人：KIKU SRL GmbH

  公开号：USPP030511P3

  公开（公告）日：2019-05-21

  ‘Gala 0502B’ apple is ‘Gala’ sport notable for its fruit, which attains a distinctive, deep purple-red color well before harvest. ‘Gala 0502B’ can be harvested in a single picking due to its early intense and even coloration.

  “Gala 0502B”苹果是一种以果实著名的“Gala”变种，果实在收获前就能呈现出深紫红色的独特颜色。由于早期的强烈均匀着色，‘Gala 0502B’可以在一次采摘中收获。
• US30511
  申请人：——

  公开号：——

  公开（公告）日：——
• PAUL R.; MENSCHIK J., HETEROCYCL. CHEM., 1979, 16, NO 2, 277-282
  作者：PAUL R.、 MENSCHIK J.

  DOI：——

  日期：——