4-chlorobutanoyl trimethyl silane | 104823-97-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 4-chlorobutanoyl trimethyl silane
• 英文别名: 4-Chloro-1-trimethylsilylbutan-1-one
• CAS: 104823-97-4
• 化学式: C₇H₁₅ClOSi
• 分子量: 178.734
• InChiKey: DPLBMIOSROHKEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.45
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-chlorobutanoyl trimethyl silane 在 盐酸 、 sodium hydroxide 、 硫化氢 作用下， 生成 2,3-Dihydrothiophen-5-yl(trimethyl)silane
  参考文献：
  名称：

  Chemistry of thioacylsilanes part 11. Cyclic and open chain α-silyl vinyl sulfides as precursors of thioannulated cyclopentenones and thiofunctionalized enones

  摘要：

  Cyclic and open chain a-silyl vinyl sulfides, obtained from thioacylsilanes, react with acid chlorides in the presence of Lewis acid to give thioannulated cyclopentenones and thiofunctionalized enones. The effect of the substituents at silicon on these reactions has been investigated. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00462-6
• 作为产物：
  描述：

  cyclopropyltrimethylsilylmethanone 在 四氯化钛 作用下， 反应 2.0h， 以41%的产率得到4-chlorobutanoyl trimethyl silane
  参考文献：
  名称：

  环丙基三甲基甲硅烷基酮被酸的开环和扩环

  摘要：

  与碳类似物相比，一系列环丙基三甲基甲硅烷基酮与酸的反应在更温和的条件下进行，得到开环产物 3-氯丙基三甲基甲硅烷基酮或扩环产物 2-trimethylsilyl-4,5-二氢呋喃衍生物。

  DOI：

  10.1246/cl.1986.181

文献信息

• Electroreductive synthesis of acylsilanes from acylimidazoles
  作者：Naoki Kise、Hiroaki Kaneko、Norihisa Uemoto、Jun-ichi Yoshida

  DOI：10.1016/0040-4039(95)01888-o

  日期：1995.11

  Electroreduction of acylimidazoles in the presence of chlorotrimethylsilane gave the corresponding acylsilanes in satisfactory yields. Acylsilanes having a functional group such as an alkoxycarbonyl or chloro group also were synthesized effectively.
• NAKAJIMA, TADASHI;MIYAJI, HIROYUKI;SEGI, MASAHITO;SUGA, SOHEI, CHEM. LETT., 1986, N 2, 181-182
  作者：NAKAJIMA, TADASHI、MIYAJI, HIROYUKI、SEGI, MASAHITO、SUGA, SOHEI

  DOI：——

  日期：——
• Chemistry of thioacylsilanes part 11. Cyclic and open chain α-silyl vinyl sulfides as precursors of thioannulated cyclopentenones and thiofunctionalized enones
  作者：Bianca F Bonini、Mauro Comes Franchini、Mariafrancesca Fochi、Germana Mazzanti、Alfredo Ricci

  DOI：10.1016/s0040-4020(97)00462-6

  日期：1997.6

  Cyclic and open chain a-silyl vinyl sulfides, obtained from thioacylsilanes, react with acid chlorides in the presence of Lewis acid to give thioannulated cyclopentenones and thiofunctionalized enones. The effect of the substituents at silicon on these reactions has been investigated. (C) 1997 Elsevier Science Ltd.
• RING OPENING AND ENLARGEMENT OF CYCLOPROPYL TRIMETHYLSILYL KETONES BY ACIDS
  作者：Tadashi Nakajima、Hiroyuki Miyaji、Masahito Segi、Sohei Suga

  DOI：10.1246/cl.1986.181

  日期：1986.2.5

  The reaction of a series of cyclopropyl trimethylsilyl ketones with acids proceeds under milder conditions compared to that of their carbon analogs to give either the ring opening products, 3-chloropropyl trimethylsilyl ketones, or the ring enlargement products, 2-trimethylsilyl-4,5-dihydrofuran derivatives.

  与碳类似物相比，一系列环丙基三甲基甲硅烷基酮与酸的反应在更温和的条件下进行，得到开环产物 3-氯丙基三甲基甲硅烷基酮或扩环产物 2-trimethylsilyl-4,5-二氢呋喃衍生物。