Boc-Cys(Mmt)-OH | 1058177-51-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Boc-Cys(Mmt)-OH
• 英文别名: (2R)-3-[(4-methoxyphenyl)-diphenylmethyl]sulfanyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
• CAS: 1058177-51-7
• 化学式: C₂₈H₃₁NO₅S
• 分子量: 493.624
• InChiKey: NQJLNVZFDFZFRD-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Boc-Cys(Mmt)-OH 、 2-(2-(2-氨基乙氧基)乙氧基)乙基氨基甲酸叔丁酯 在 N,N'-羰基二咪唑 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以64%的产率得到
  参考文献：
  名称：

  Biochemical analysis of cellular target of S-trityl-l-cysteine derivatives using affinity matrix

  摘要：

  Biochemical analysis of the cellular target of S-trityl-L-cysteine (STLC) derivatives was performed by using the newly synthesized STLC derivative-immobilized affinity beads (3d). The affinity beads efficiently captured KSP in HCT116 cytoplasmic cell lysate. The results obtained from pull-down and competition experiments using 3d with STLC derivatives provided the first evidence for direct interaction of these derivatives with KSP in cancer cells. Design, synthesis and application of 3d were reported. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.088
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 S-<4-monomethoxytrityl>-(L)-cysteine 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成 Boc-Cys(Mmt)-OH
  参考文献：
  名称：

  Biochemical analysis of cellular target of S-trityl-l-cysteine derivatives using affinity matrix

  摘要：

  Biochemical analysis of the cellular target of S-trityl-L-cysteine (STLC) derivatives was performed by using the newly synthesized STLC derivative-immobilized affinity beads (3d). The affinity beads efficiently captured KSP in HCT116 cytoplasmic cell lysate. The results obtained from pull-down and competition experiments using 3d with STLC derivatives provided the first evidence for direct interaction of these derivatives with KSP in cancer cells. Design, synthesis and application of 3d were reported. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.088

文献信息

• Biochemical analysis of cellular target of S-trityl-l-cysteine derivatives using affinity matrix
  作者：Makiko Shimizu、Hirosuke Ishii、Naohisa Ogo、Kenji Matsuno、Akira Asai

  DOI：10.1016/j.bmcl.2010.01.088

  日期：2010.3

  Biochemical analysis of the cellular target of S-trityl-L-cysteine (STLC) derivatives was performed by using the newly synthesized STLC derivative-immobilized affinity beads (3d). The affinity beads efficiently captured KSP in HCT116 cytoplasmic cell lysate. The results obtained from pull-down and competition experiments using 3d with STLC derivatives provided the first evidence for direct interaction of these derivatives with KSP in cancer cells. Design, synthesis and application of 3d were reported. (C) 2010 Elsevier Ltd. All rights reserved.