trans-N-trityl-4-hydroxy-L-proline | 80514-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: trans-N-trityl-4-hydroxy-L-proline
• 英文别名: (2S,4R)-4-hydroxy-1-tritylpyrrolidine-2-carboxylic acid
• CAS: 80514-79-0
• 化学式: C₂₄H₂₃NO₃
• 分子量: 373.452
• InChiKey: OFLPLXXUYDYSJP-YADHBBJMSA-N

物化性质

• 沸点：
  544.5±50.0 °C(Predicted)
• 密度：
  1.268±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  trans-N-trityl-4-hydroxy-L-proline 在 氢氧化钾 、 三苯基膦 、 苯甲酸 、 偶氮二甲酸二乙酯 作用下， 以 甲苯 为溶剂， 反应 6.0h， 生成 N-trityl-cis-4-hydroxy-L-proline
  参考文献：
  名称：

  Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers

  摘要：

  C2R-Fluoro substituted DC-81 and its dimers have been synthesized that exhibit significant DNA-binding ability, particularly the five carbon alkane spacer compound (6c) showed the helix melting temperature (Delta T-m) of 18.8 degrees C after incubation of 36 h at 37 degrees C. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.10.070
• 作为产物：
  描述：

  反式-4-羟基-L-脯氨酸甲酯 、 三苯基氯甲烷 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 trans-N-trityl-4-hydroxy-L-proline
  参考文献：
  名称：

  Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers

  摘要：

  C2R-Fluoro substituted DC-81 and its dimers have been synthesized that exhibit significant DNA-binding ability, particularly the five carbon alkane spacer compound (6c) showed the helix melting temperature (Delta T-m) of 18.8 degrees C after incubation of 36 h at 37 degrees C. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.10.070

文献信息

• Papaioannou, Dionissios; Stavropoulos, George; Karagiannis, Kostas, Acta Chemica Scandinavica, 1990, vol. 44, # 3, p. 243 - 251
  作者：Papaioannou, Dionissios、Stavropoulos, George、Karagiannis, Kostas、Francis, George W.、Brekke, Trond、Aksnes, Dagfinn W.

  DOI：——

  日期：——
• PAPAIOANNOU, DIONISSIOS;STAVROPOULOS, GEORGE;KARAGIANNIS, KOSTAS;FRANCIS,+, ACTA CHEM. SCAND., 44,(1990) N, C. 243-251
  作者：PAPAIOANNOU, DIONISSIOS、STAVROPOULOS, GEORGE、KARAGIANNIS, KOSTAS、FRANCIS,+

  DOI：——

  日期：——
• Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers
  作者：Ahmed Kamal、D. Rajasekhar Reddy、P.S. Murali Mohan Reddy

  DOI：10.1016/j.bmcl.2006.10.070

  日期：2007.2

  C2R-Fluoro substituted DC-81 and its dimers have been synthesized that exhibit significant DNA-binding ability, particularly the five carbon alkane spacer compound (6c) showed the helix melting temperature (Delta T-m) of 18.8 degrees C after incubation of 36 h at 37 degrees C. (c) 2006 Elsevier Ltd. All rights reserved.