1-(2-chloro-phenyl)-1,1-diphenyl-ethane | 854220-15-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-(2-chloro-phenyl)-1,1-diphenyl-ethane
• 英文别名: 1-(2-Chlor-phenyl)-1,1-diphenyl-aethan；1-Chloro-2-(1,1-diphenylethyl)benzene
• CAS: 854220-15-8
• 化学式: C₂₀H₁₇Cl
• 分子量: 292.808
• InChiKey: OAWJODWETQKTLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-(2-chloro-phenyl)-1,1-diphenyl-ethane 在 吡啶 、 乙醚 、 苯 作用下， 生成 2-(1,1-diphenyl-ethyl)-benzophenone-imine; hydrochloride
  参考文献：
  名称：

  Aromatic Cyclodehydration. XI.¹ The Mechanism of the Cyclization of o-Benzylphenones^2a,b

  摘要：

  DOI：

  10.1021/ja01245a026
• 作为产物：
  描述：

  (2-氯苯基)二苯基甲醇 在 盐酸 、 乙醚 、 苯 作用下， 生成 1-(2-chloro-phenyl)-1,1-diphenyl-ethane
  参考文献：
  名称：

  Aromatic Cyclodehydration. XI.¹ The Mechanism of the Cyclization of o-Benzylphenones^2a,b

  摘要：

  DOI：

  10.1021/ja01245a026

文献信息

• CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP3636807A1

  公开（公告）日：2020-04-15

  The present inventors have found that when screening for cyclic peptide compounds that can specifically bind to a target molecule, the use of a library including cyclic peptide compounds having a long side chain in the cyclic portion can improve the hit rate for cyclic peptide compounds that can specifically bind to the target molecule. Meanwhile, the present inventors have found that tryptophan and tyrosine residues, which have conventionally been used in oral low molecular-weight pharmaceuticals and are amino acid residues having an indole skeleton or a hydroxyphenyl group, are not suitable for peptides intended to attain high membrane permeability.

  本发明人发现，在筛选能与目标分子特异性结合的环肽化合物时，使用包括环状部分具有长侧链的环肽化合物库，可以提高能与目标分子特异性结合的环肽化合物的命中率。同时，本发明者发现色氨酸和酪氨酸残基不适合用于旨在获得高膜渗透性的肽，这两种残基通常用于口服低分子量药物，是具有吲哚骨架或羟基苯基的氨基酸残基。
• PEPTIDE NUCLEIC ACID (PNA) MONOMERS WITH AN ORTHOGONALLY PROTECTED ESTER MOIETY AND NOVEL INTERMEDIATES AND METHODS RELATED THERETO
  申请人：VERA THERAPEUTICS, INC.

  公开号：US20210171437A1

  公开（公告）日：2021-06-10

  The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA monomer precursors (e.g. PNA Monomer Esters, Backbone Esters and Backbone Ester Acid Salts, as described below) that can be used to prepare PNA monomers wherein said PNA monomers can be used to prepare said PNA oligomers. In some embodiments, the disclosure features sulfonic acid salts of Backbone Ester compounds, which sulfonic acid salts generally tend to be crystalline and can be obtained in reasonably good yield, often without requiring any chromatographic purification of the reaction product of the Backbone Ester synthesis reaction. This disclosure also pertains to novel methods for the synthesis of said Backbone Ester compounds and novel methods for the formation of the related sulfonic acid salts. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethy-(TCE), 2,2,2-tribromoethyl-(TBE), 2-iodoethyl-groups (2-IE) and 2-bromoethyl-(2-BrE) as the ester group. These particular ester groups can be removed under conditions where both Boc and Fmoc protected amine groups are stable.
• PEPTIDE NUCLEIC ACID (PNA) MONOMERS WITH AN ORTHOGONALLY PROTECTED ESTER MOIETY
  申请人：VERA THERAPEUTICS, INC.

  公开号：US20210206809A1

  公开（公告）日：2021-07-08

  This application pertains to orthogonally protected esters of peptide nucleic acid (PNA) monomers, which ester groups can be removed under conditions that permit typical backbone and side chain acid- and base-labile protecting groups to remain substantially intact thereby permitting the high yield of PNA monomer carboxylic acids that are suitable for use in PNA oligomer synthesis. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethyl (TCE), 2,2,2-tribromoethyl (TBE), 2-bromoethyl (2-BE) and 2-iodoethyl groups (2-IE). This invention also pertains to novel methods for the synthesis of Backbone Ester compounds and related Backbone Ester Acid Salts.
• US9642865B2
  申请人：——

  公开号：US9642865B2

  公开（公告）日：2017-05-09
• Aromatic Cyclodehydration. XI.¹ The Mechanism of the Cyclization of o-Benzylphenones^2a,b
  作者：Charles K. Bradsher、E. Studley Smith

  DOI：10.1021/ja01245a026

  日期：1943.5